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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/26420

Title: Associations of leptin, insulin and lipids with retinal microvasculature in children and adolescents
Authors: van Aart, Carola J. C.
Michels, Nathalie
Sioen, Isabelle
De Decker, Annelies
Nawrot, Tim S.
De Henauw, Stefaan
Issue Date: 2018
Abstract: Background: We investigated whether cardiometabolic risk factors measured in serum (total cholesterol [TC], high-density lipoprotein [HDL], triglyceride, leptin, insulin, glucose and insulin resistance) are associated with the retinal microvasculature, a marker of cardiovascular aging, in healthy children and adolescents. Moreover, we tested whether these associations are due to direct biological effects or more indirectly due to adiposity-related side effects. Methods: We recruited 168 healthy Flemish children (7-16 years old, 54.8% boys). Blood samples and retinal photographs were taken during clinical examinations. Arteriolar and venular vessel calibers were calculated using a semi-automated computer program. Multivariable regression models were used and adjusted for age, sex, mean arterial pressure (MAP) and alternate retinal caliber. In a second step, we adjusted for body mass index z-score (zBMI). Results: Only continuous serum leptin was associated with retinal parameters, i.e. wider arterioles; however, this disappeared after adjustment for zBMI. Children with high cardiometabolic risk factors (>90th percentile for serum leptin, insulin and insulin resistance) had wider arterioles compared to children with lower concentrations, even after additional adjustment for zBMI. No significant associations were found with lipids. Conclusions: In this healthy population of children and adolescents, the hormones insulin and leptin and insulin resistance were associated with retinal microvasculature alterations, mainly in children with high cardiometabolic factors (>90th percentile), while lipids were not. These associations were independent of zBMI.
Notes: van Aart, CJC (reprint author), Univ Ghent, Fac Med & Hlth Sci, Dept Publ Hlth, Pintelaan 185 4K3, B-9000 Ghent, Belgium. Carola.vanAart@ugent.be
URI: http://hdl.handle.net/1942/26420
DOI: 10.1515/jpem-2017-0374
ISI #: 000423677900005
ISSN: 0334-018X
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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