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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/26402

Title: Heart Failure with Myocardial Recovery - The Patient Whose Heart Failure Has Improved: What Next?
Authors: Nijst, Petra
Martens, Pieter
Mullens, Wilfried
Issue Date: 2017
Abstract: In an important number of heart failure (HF) patients substantial or complete myocardial recovery occurs. In the strictest sense, myocardial recovery is a return to both normal structure and function of the heart. HF patients with myocardial recovery or recovered ejection fraction (EF; HFrecEF) are a distinct population of HF patients with different underlying etiologies, demographics, comorbidities, response to therapies and outcomes compared to HF patients with persistent reduced (HFrEF) or preserved ejection fraction (HFpEF). Improvement of left ventricular EF has been systematically linked to improved quality of life, lower rehospitalization rates and mortality. However, mortality and morbidity in HFrecEF patients remain higher than in the normal population. Also, persistent abnormalities in biomarker and gene expression profiles in these patients lends weight to the hypothesis that pathological processes are ongoing. Currently, there remains a lack of data to guide the management of HFrecEF patients. This review will discuss specific characteristics, pathophysiology, clinical implications and future needs for HFrecEF. (C) 2017 Elsevier Inc. All rights reserved.
Notes: [Nijst, Petra; Martens, Pieter; Mullens, Wilfried] Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium. [Nijst, Petra; Martens, Pieter] Hasselt Univ, Doctoral Sch Med & Life Sci, Diepenbeek, Belgium. [Mullens, Wilfried] Hasselt Univ, Biomed Res Inst, Fac Med & Life Sci, Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/26402
DOI: 10.1016/j.pcad.2017.05.009
ISI #: 000413610600008
ISSN: 0033-0620
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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