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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/2636

Title: Insights into the immunopathogenesis of multiple sclerosis
Authors: HELLINGS, Niels
Issue Date: 2002
Citation: IMMUNOLOGIC RESEARCH, 25(1). p. 27-51
Abstract: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Significant progress has been made in our understanding of the etiology of MS. MS is widely believed to be an autoimmune disease that results from aberrant immune responses to CNS antigens. T cells are considered to be crucial in orchestrating an immunopathological cascade that results in damage to the myelin sheath. This review summarizes the currently available data supporting the idea that myelin reactive T cells are actively involved in the immunopathogenesis of MS. Some of the therapeutic strategies for MS are discussed with a focus on immunotherapies that aim to specifically target the myelin reactive T cells.
Notes: Univ Limburg, DWI, Biomed Onderzock Inst, Autoimmune Dis Unit, Centrum, Belgium. Limburgs Univ Centrum, Biomed Res Inst, Centrum, Belgium. Transnatl Univ, Sch Life Sci, Diepenbeek, Belgium.Stinissen, P, Univ Limburg, DWI, Biomed Onderzock Inst, Autoimmune Dis Unit, Centrum, Belgium.
URI: http://hdl.handle.net/1942/2636
DOI: 10.1385/IR:25:1:27
ISI #: 000173854000002
ISSN: 0257-277X
Category: A1
Type: Journal Contribution
Validation: ecoom, 2003
Appears in Collections: Research publications

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