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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/26276

Title: Macrolide resistance in Mycoplasma genitalium from female sex workers in Belgium
Authors: Coorevits, Liselotte
Traen, Ans
Binge, Luk
Descheemaeker, Patrick
Boelens, Jerina
Reynders, Marijke
Padalko, Elizaveta
Issue Date: 2018
Abstract: Objectives: Mycoplasma genitalium is emerging as an aetiological agent of sexually transmitted infections (STIs). Although M. genitalium is commonly treated with azithromycin, macrolide resistance associated with point mutations in the 23S rRNA gene is emerging. Methods: In this study, the prevalence of M. genitalium and macrolide resistance in female sex workers (FSW) in Belgium was evaluated by a prospective study conducted between 2015 and 2016. Vaginal swabs were sampled from 303 FSW who underwent testing for M. genitalium along with standard STI screening. All samples positive for M. genitalium were subsequently tested for mutations associated with macrolide resistance. Results: M. genitalium was detected in 10.8% of participants and macrolide resistance-associated mutations (A2058G and A2059G) were found in 6.5% of isolates. Conclusions: M. genitalium is clearly present in FSW in Belgium. In contrast to other reports, for now the occurrence of macrolide resistance appears limited in this specific target population. (C) 2017 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.
Notes: Coorevits, L (reprint author), Ghent Univ Hosp, Dept Lab Med, Corneel Heymanslaan 10, B-9000 Ghent, Belgium, liselotte.coorevits@ugent.be
URI: http://hdl.handle.net/1942/26276
DOI: 10.1016/j.jgar.2017.09.018
ISI #: 000428273500037
ISSN: 2213-7165
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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