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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/26274

Title: Diamond microelectrode arrays for in vitro neuronal recordings
Authors: McDonald, Matthew
Monaco, Antonina
Vahidpour, Farnoosh
Haenen, Ken
Giugliano, Michele
Nesladek, Milos
Issue Date: 2017
Citation: MRS COMMUNICATIONS, 7(3), p. 683-690
Abstract: A novel microfabrication technique for microelectrode arrays (MEAs) with a full diamond-cell interface is demonstrated. Boron-doped nano-crystalline diamond (BNCD) is used as a conductive electrode material on metal tracks insulated by intrinsic NCD. MEAs successfully recorded spontaneous electrical activity in rat primary cortical neuronal cultures. Patch-clamp measurements show no alterations to cell membrane passive properties or active firing response, for cell developing ex vivo on diamond. Impedance analysis revealed low impedance magnitude of BNCD electrodes, suitable for multi-unit neuronal recordings. Additionally, the impedance phase of the fabricated electrodes shows a high degree of capacitive coupling, ideal for neuron stimulation.
Notes: [McDonald, Matthew; Vahidpour, Farnoosh; Haenen, Ken; Nesladek, Milos] Hasselt Univ, Inst Mat Res, B-3590 Diepenbeek, Belgium. [Monaco, Antonina; Giugliano, Michele] Univ Antwerp, Dept Biomed Sci, B-2610 Antwerp, Belgium. [Giugliano, Michele] Swiss Fed Inst Technol Lausanne, Brain Mind Inst, Lausanne, Switzerland. [Giugliano, Michele] Univ Sheffield, Dept Comp Sci, Sheffield S1 4DP, S Yorkshire, England. [Nesladek, Milos] Interuniv Microelect Ctr IMEC, B-3001 Heverlee, Belgium.
URI: http://hdl.handle.net/1942/26274
DOI: 10.1557/mrc.2017.62
ISI #: 000412602400044
ISSN: 2159-6859
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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