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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/26253

Title: Comorbidities and medication use in patients with a recent clinical fracture at the Fracture Liaison Service
Authors: Vranken, L.
Wyers, C. E.
Van der Velde, R. Y.
Janzing, H. M.
Kaarsemaker, S.
Geusens, Piet P.
van den Bergh, Joop P.
Issue Date: 2018
Publisher: SPRINGER LONDON LTD
Citation: OSTEOPOROSIS INTERNATIONAL, 29(2), p. 397-407
Abstract: In this cross-sectional study, two-thirds of Fracture Liaison Service (FLS) patients had comorbidities and medications associated with increased bone- or fall-related fracture risk. Bone-related and fall-related fracture risk (BRR and FRR) were associated with age and fracture type, but not with gender or BMD. Systematic evaluation of these factors leads to a more profound assessment in FLS care. This study is a systematic evaluation of comorbidities and medications associated with increased fracture risk in patients aged 50-90 years with a recent fracture visiting the FLS. In this cross-sectional cohort study, comorbidities were classified according to ICD-10 and medications according to the Anatomic Therapeutic Chemical (ATC) classification and further categorized into those associated BRR and FRR. Of 1282 patients (72% women; 65 +/- 9 years), 53% had at least one BRR, 46% had at least one FRR, and 66% at least one BRR and/or FRR. At least one BRR, as well as at least one FRR were associated with age, BMI, and fracture type, but not with gender or BMD. The proportion of patients with only BRR (+/- 20%) or only FRR (+/- 10%) was similar among ages, gender, BMI, fracture type, and BMD. The combination of at least one BRR and at least one FRR was significantly associated with age, BMI, and major fractures, but not with gender or BMD. Comorbidities and medications associated with increased fracture risk are present in two-thirds of patients visiting the FLS. In addition, the proportion of patients having a combination of BRR and FRR increased significantly with age, BMI, and fracture severity. This indicates that systematic evaluation of these factors is important for a more profound assessment of subsequent fracture risk in FLS care.
Notes: [Vranken, L.; Wyers, C. E.; Van der Velde, R. Y.; Van den Bergh, J. P.] VieCuri Med Ctr, Dept Internal Med, POB 1926, NL-5900 BX Venlo, Netherlands. [Vranken, L.; Wyers, C. E.; Van der Velde, R. Y.; Van den Bergh, J. P.] Maastricht Univ Med Ctr Maastricht UMC, NUTRIM Sch Nutr & Translat Res Metab, Dept Internal Med, POB 616, NL-6200 MD Maastricht, Netherlands. [Janzing, H. M.] VieCuri Med Ctr, Dept Surg, POB 1926, NL-5900 BX Venlo, Netherlands. [Kaarsemaker, S.] VieCuri Med Ctr, Dept Orthopaed Surg, POB 1926, NL-5900 BX Venlo, Netherlands. [Geusens, P. P.] Maastricht Univ Med Ctr Maastricht UMC, Dept Internal Med, Subdiv Rheumatol, CAPHRI, POB 616, NL-6200 MD Maastricht, Netherlands. [Geusens, P. P.; Van den Bergh, J. P.] Hasselt Univ, Biomed Res Ctr, Agoralaan, B-3590 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/26253
DOI: 10.1007/s00198-017-4290-y
ISI #: 000425528400013
ISSN: 0937-941X
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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