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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/26235

Title: Telemonitoring-based feedback improves adherence to non-vitamin K antagonist oral anticoagulants intake in patients with atrial fibrillation
Authors: Desteghe, Lien
Vijgen, Johan
Koopman, Pieter
Dilling-Boer, Dagmara
Schurmans, Joris
Dendale, Paul
Heidbuchel, Hein
Issue Date: 2018
Citation: EUROPEAN HEART JOURNAL, 39(16), p. 1394-1403
Abstract: Aims To evaluate the effect of telemonitoring on adherence to non-vitamin K antagonist oral anticoagulants (NOACs) in atrial fibrillation (AF) patients. Methods and results A randomized, single-blind, crossover, controlled trial in 48 AF patients on once or twice daily (OD or BID) NOAC. The Medication Event Monitoring System tracked NOAC intake during three phases of 3 months each: daily telemonitoring, telemonitoring with immediate telephone feedback in case of intake errors, and an observation phase without daily transmissions. Unprotected days were defined as >= 3 or >= 1 consecutively missed doses for a BID or OD NOAC, respectively, or excess dose intake. Cost-effectiveness was calculated based on anticipated stroke reduction derived from patients' risk profile and measured intake. Persistence over the entire study was 98%. Telemonitoring-only already led to very high taking and regimen adherence (97.4% respectively 93.8%). Nevertheless, direct feedback further improved both to 99.0% and 96.8%, respectively (P < 0.001 respectively P =0.002). Observation without daily monitoring resulted in a significant waning of taking adherence (94.3%; P =0.049). Taking adherence was significantly higher for OD compared to BID NOAC, although unprotected days were similar. Feedback intervention had an incremental cost of (sic)344 289 to prevent one stroke, but this could be as low as (sic)15 488 in high-risk patients with low adherence and optimized technology. Conclusion Telemonitoring resulted in high NOAC adherence due to the notion of being watched, as evidenced by the rapid decline during the observation period. Feedback further optimized adherence. Telemonitoring with or without feedback may be a cost-effective approach in high-risk patients deemed poorly adherent.
Notes: Desteghe, L (reprint author), Hasselt Univ, Fac Med & Life Sci, Martelarenlaan 42, B-3500 Hasselt, Belgium, Jessa Hosp, Heart Ctr Hasselt, Stadsomvaart 11, B-3500 Hasselt, Belgium. lien.desteghe@uhasselt.be
URI: http://hdl.handle.net/1942/26235
DOI: 10.1093/eurheartj/ehx762
ISI #: 000430725600008
ISSN: 0195-668X
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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