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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/26196

Title: The Role of Genetic Variants in the Association between Dietary Acrylamide and Advanced Prostate Cancer in the Netherlands Cohort Study on Diet and Cancer
Authors: Perloy, Andy
Schouten, Leo J.
van den Brandt, Piet A.
Godschalk, Roger
van Schooten, Frederik-Jan
Hogervorst, Janneke G. F.
Issue Date: 2018
Citation: NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 70(4), p. 620-631
Abstract: To investigate the association between dietary acrylanide and advanced prostate cancer, we examined acrylamide-gene interactions for advanced prostate cancer risk by using data from the Netherlands Cohort Study.Participants (n = 58,279 men) completed a baseline food frequency questionnaire (FFQ), from which daily acrylamide intake was calculated. At baseline, 2,411 men were randomly selected from the full cohort for case-cohort analysis. Fifty eight selected single nucleotide polymorphisms (SNPs) and two gene deletions in genes in acrylamide metabolism, DNA repair, sex steroid systems, and oxidative stress were analyzed. After 20.3years of follow-up, 1,608 male subcohort members and 948 advanced prostate cancer cases were available for Cox analysis.Three SNPs showed a main association with advanced prostate cancer risk after multiple testing correction: catalase (CAT) rs511895, prostaglandin-endoperoxide synthase 2 (PTGS2) rs5275, and xeroderma pigmentosum group C (XPC) rs2228001. With respect to acrylamide-gene interactions, only rs1800566 in NAD(P)H quinone dehydrogenase 1 (NQO1) and rs2301241 in thioredoxin (TXN) showed a nominally statistically significant multiplicative interaction with acrylamide intake for advanced prostate cancer risk. After multiple testing corrections, none were statistically significant.In conclusion, no clear evidence was found for interaction between acrylamide intake and selected genetic variants for advanced prostate cancer risk.
Notes: Schouten, LJ (reprint author), Maastricht Univ, GROW Sch Oncol & Dev Biol, Dept Epidemiol, Maastricht, Netherlands. lj.schouten@maastrichtuniversity.nl
URI: http://hdl.handle.net/1942/26196
DOI: 10.1080/01635581.2018.1460682
ISI #: 000432214600009
ISSN: 0163-5581
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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