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|Title: ||Prognostic impact of tumour-stroma ratio in early-stage oral tongue cancers|
|Authors: ||Almangush, Alhadi|
Makinen, Laura K.
Kauppila, Joonas H.
Kowalski, Luiz P.
Makitie, Antti A.
Coletta, Ricardo D.
|Issue Date: ||2018|
|Citation: ||HISTOPATHOLOGY, 72(7), p. 1128-1135|
|Abstract: ||Aims: Oral tongue squamous cell carcinoma (OTSCC) has a relatively poor outcome, and there is a need to identify better prognostic factors. Recently, tumour-stroma ratio (TSR) has been associated with prognosis in several cancers. The aim of this multi-institutional study was to evaluate the prognostic value of TSR from original haematoxylin and eosin (HE)-stained tumour-resection slides in a series of early-stage (cT1-2N0) OTSCC patients. Methods and results: A TSR cutoff value of 50% was used to divide the patients into stroma-rich (>= 50%) and stroma-poor (<50%) groups. The relationships between TSR and clinicopathological characteristics of 311 early-stage OTSCC cases were analysed. The prognostic value of TSR in OTSCC was calculated separately and in combination with a previously published cancer cell budding and depth of invasion (BD) prognostic model. A total of 89 cases (28.6%) belonged to the stroma-rich group. In a multivariate analysis, the stroma-rich group had worse disease-free survival, with a hazard ratio (HR) of 1.81 [95% confidence interval (CI) 1.17-2.79, P = 0.008], and higher cancer-related mortality (HR 1.71, 95% CI 1.02-2.86, P = 0.03). The combination of the highest-risk parameter scores of TSR and the BD model showed significant correlations with recurrence rate (HR 3.42, 95% CI 1.71-6.82, P = 0.004) and cancer-related mortality (HR 11.63, 95% CI 3.83-35.31, P < 0.001). Conclusions: We conclude that TSR is a simple histopathological feature that is useful for prognostication of early-stage OTSCC, and suggest that TSR analyses in association with BD score could be included in routine clinical pathology reports for HE-stained slides.|
|Notes: ||Almangush, A (reprint author), Univ Helsinki, Dept Pathol, Haartmaninkatu 3,POB 21, FIN-00014 Helsinki, Finland. firstname.lastname@example.org|
|ISI #: ||000431993600006|
|Type: ||Journal Contribution|
|Appears in Collections: ||Research publications|
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