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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/25999

Title: GABA levels and measures of intracortical and interhemispheric excitability in healthy young and older adults: a MRS-TMS study
Authors: Hermans, Lize
Levin, Oron
Maes, Celine
van Ruitenbeek, Peter
Heise, Kristin-Friederike
Edden, Richard A.E.
Puts, Nicolaas A.J.
Peeters, Ronald
King, Bradley R.
Meesen, Raf L.J.
Leunissen, Inge
Swinnen, Stephan P.
Cuypers, Koen
Issue Date: 2018
Citation: NEUROBIOLOGY OF AGING, 65, p. 168-177
Abstract: Edited magnetic resonance spectroscopy (MRS) and transcranial magnetic stimulation (TMS) have often been used to study the integrity of the GABAergic neurotransmission system in healthy aging. To investigate whether the measurement outcomes obtained with these 2 techniques are associated with each other in older human adults, gamma-aminobutyric acid (GABA) levels in the left sensorimotor cortex were assessed with edited MRS in 28 older (63e74 years) and 28 young adults (19e34 years). TMS at rest was then used to measure intracortical inhibition (short-interval intracortical inhibition/longinterval intracortical inhibition), intracortical facilitation, interhemispheric inhibition from left to right primary motor cortex (M1) and recruitment curves of left and right M1. Our observations showed that short-interval intracortical inhibition and long-interval intracortical inhibition in the left M1 were reduced in older adults, while GABA levels did not significantly differ between age groups. Furthermore, MRS-assessed GABA within left sensorimotor cortex was not correlated with TMS-assessed cortical excitability or inhibition. These observations suggest that healthy aging gives rise to altered inhibition at the postsynaptic receptor level, which does not seem to be associated with MRS-assessed GABAĆ¾ levels.
Notes: Cuypers, K (reprint author), Katholieke Univ Leuven, Grp Biomed Sci, Movement Control & Neuroplast Res Grp, Tervuursevest 101, B-3001 Leuven, Belgium, koen.cuypers@kuleuven.be
URI: http://hdl.handle.net/1942/25999
DOI: 10.1016/j.neurobiolaging.2018.01.023
ISI #: 000428233700017
ISSN: 0197-4580
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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