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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/25996

Title: Three-dimensional organization and dynamics of the genome
Authors: Szałaj, Przemysław
Plewczynski, Dariusz
Issue Date: 2018
Citation: CELL BIOLOGY AND TOXICOLOGY,
Status: Early View
Abstract: Genome is a complex hierarchical structure, and its spatial organization plays an important role in its function. Chromatin loops and topological domains form the basic structural units of this multiscale organization and are essential to orchestrate complex regulatory networks and transcription mechanisms. They also form higher-order structures such as chromosomal compartments and chromosome territories. Each level of this intrinsic architecture is governed by principles and mechanisms that we only start to understand. In this review, we summarize the current view of the genome architecture on the scales ranging from chromatin loops to the whole genome. We describe cell-to-cell variability, links between genome reorganization and various genomic processes, such as chromosome X inactivation and cell differentiation, and the interplay between different experimental techniques.
URI: http://hdl.handle.net/1942/25996
DOI: 10.1007/s10565-018-9428-y
ISSN: 0742-2091
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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