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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/25973

Title: Retinal microcirculation and leukocyte telomere length in the general population
Authors: Martens, Dries S.
Wei, Fang-Fei
Cox, Bianca
Plusquin, Michelle
Thijs, Lutgarde
Winckelmans, Ellen
Zhang, Zhen-Yu
Nawrot, Tim Steve
Staessen, Jan A.
Issue Date: 2018
Citation: Scientific Reports, 8 (Art N° 7095)
Abstract: Retinal arteriolar narrowing increases with age and predict adverse cardiovascular outcomes. Telomere length keeps track of the division of somatic cells and is a biomarker of biological age. We investigated to what extent retinal arteriolar diameters are associated with biological age, as captured by leukocyte telomere length (LTL). In 168 randomly selected Flemish participants from the family-based population study FLEMENGHO (mean age, 46.2 years) at baseline, of whom 85 underwent a follow-up examination (median, 4.1 years), we post-processed nonmydriatic retinal photographs and measured LTL. In men only, central retinal arteriolar equivalents (CRAE) and arteriole-to-venule ratio (AVR) were associated with LTL with stronger associations at higher age and body mass index. In men aged 57.6 years (75th percentile) a 20% shorter LTL was associated with a decrease in CRAE of 4.57µm. A 20% shorter LTL was associated with a decrease of 5.88µm in CRAE at a BMI of 29.9kg/m2 (75th percentile). Similar associations were observed between AVR and LTL. In women, no retinal microvascular traits were associated with LTL. Retinal arteriolar narrowing in men but not in women is associated with biological age. Our fndings support the idea that avoiding overweight contributes to maintaining a healthier microcirculation.
Notes: Staessen, JA (reprint author), Univ Leuven, KU Leuven Dept Cardiovasc Sci, Res Unit Hypertens & Cardiovasc Epidemiol, Studies Coordinating Ctr, Leuven, Belgium. jan.staessen@med.kuleuven.be
URI: http://hdl.handle.net/1942/25973
DOI: 10.1038/s41598-018-25165-6
ISI #: 000431402200005
ISSN: 2045-2322
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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