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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/25957

Title: Performed and perceived walking ability in relation to the Expanded Disability Status Scale in persons with multiple sclerosis.
Authors: Langeskov-Christensen, D.
Feys, Peter
Baert, Ilse
Riemenschneider, M.
Stenager, E.
Dalgas, U.
Issue Date: 2017
Citation: Journal of the neurological sciences, 382, p. 131-136
Abstract: Background: The severity of walking impairment in persons with multiple sclerosis (pwMS) at different levels on the expanded disability status scale (EDSS) is unclear. Furthermore, it is unclear if the EDSS is differently related to performed- and perceived walking capacity tests. Aims: To quantify walking impairment and perceived impact of MS on walking according to EDSS scores and to examine the relations between these parameters in pwMS. Methods: EDSS was collected by neurologists and walking was assessed by the timed 25 ft walk test (T25FWT), two minute walk test (2MWT), six minute walk test (6MWT) and the 12-item MS walking scale (MSWS-12) in 474 PwMS with mild (EDSS 1–4: n = 200) to moderate (EDSS 4.5–6.5: n = 274) MS. Magnitude of walking impairment was calculated and related to EDSS. Results: Compared to predicted values in healthy controls, walking speed was reduced by 41.5 ± 25.8% in the 6MWT for the total MS group and by 21.8 ± 20.2% and 55.8 ± 19.1% in the mild and moderate MS subgroups, respectively. The EDSS score showed the strongest relationship to the 2MWT and the 6MWT in the total MS group (r = −0.76, p < 0.0001), to the MSWS-12 score in the mild MS group (r = 0.56, p < 0.0001), and to the 2MWT in the moderate MS group (r = −0.50, p < 0.0001). Conclusion: In pwMS (EDSS scores 1–6.5), walking speed is on average reduced by ~40% when compared to predicted values in healthy controls, and impairments are already present at early disease stages, suggesting early initiation of rehabilitation. The 2MWT and 6MWT show the strongest relationship to EDSS, but the MSWS12 identify impairments more gradually at low EDSS scores.
Notes: [Langeskov-Christensen, D.; Riemenschneider, M.; Dalgas, U.] Aarhus Univ, Dept Publ Hlth, Sect Sport Sci, Dalgas Ave 4, DK-8000 Aarhus C, Denmark. [Feys, P.; Baert, I.] Hasselt Univ, Fac Med & Life Sci, BIOMED Biomed Res Inst, REVAL, Hasselt, Belgium. [Stenager, E.] Univ Southern Denmark, Inst Reg Hlth Res, Odense, Denmark. [Stenager, E.] MS Clin Southern Jutland Sonderborg Esbjerg Koldi, Dept Neurol, Sonderborg, Denmark.
URI: http://hdl.handle.net/1942/25957
DOI: 10.1016/j.jns.2017.09.049
ISI #: 000415782700029
ISSN: 0022-510X
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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