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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/2579

Title: Dynamic modelling of a challenge-escalation cross-over study of treatment of capsaicin-induced coughing
Authors: LINDSEY, James
Stevens, JW
Jones, B
Jackson, D
Issue Date: 2002
Citation: STATISTICS IN MEDICINE, 21(20). p. 3023-3033
Abstract: in a complex seven-period cross-over trial to study the effects of a drug in attenuating capsaicin-induced coughing, counts of numbers of coughs were recorded 32 times in each period. Subjects were subjected to four escalating levels of capsaicin at each of one and five hours after treatment, with counts of coughs being recorded in four one-minute intervals at each level. Such longitudinal count studies often show considerable individual variability about any regression curve that might be fitted. We develop a non-linear autoregressive model for such count data that also allows for overdispersion. Copyright (C) 2002 John Wiley Sons, Ltd.
Notes: Univ Limburg, B-3590 Diepenbeek, Belgium. GlaxoSmithKline, Harlow, Essex, England. Astra R&D, Loughborough, Leics, England.Lindsey, JK, Univ Limburg, B-3590 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/2579
DOI: 10.1002/sim.1248
ISI #: 000178591400003
ISSN: 0277-6715
Category: A1
Type: Journal Contribution
Validation: ecoom, 2003
Appears in Collections: Research publications

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