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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/25718

Title: A systematic review of varicella seroprevalence in European countries before universal childhood immunization: deriving incidence from seroprevalence data
Authors: Bollaerts, Kaatje
Riera-Montes, Margarita
Heininger, Ulrich
Hens, Niel
Souverain, Audrey
Verstraeten, Thomas
Hartwig, Susanne
Issue Date: 2017
Citation: EPIDEMIOLOGY AND INFECTION, 145(13), p. 2666-2677
Abstract: Surveillance systems for varicella in Europe are highly heterogeneous or completely absent. We estimated the varicella incidence based on seroprevalence data, as these data are largely available and not biased by under-reporting or underascertainment. We conducted a systematic literature search for varicella serological data in Europe prior to introduction of universal varicella immunization. Age-specific serological data were pooled by country and serological profiles estimated using the catalytic model with piecewise constant force of infection. From the estimated profiles, we derived the annual incidence of varicella infection (/100.000) for six age groups (<5, 5-9, 10-14, 15-19, 20-39 and 40-65 years). In total, 43 studies from 16 countries were identified. By the age of 15 years, over 90% of the population has been infected by varicella in all countries except for Greece (86.6%) and Italy (85.3%). Substantial variability across countries exists in the age-specific annual incidence of varicella primary infection among the <5 years old (from 7052 to 16 122 per 100 000) and 5-9 years old (from 3292 to 11 798 per 100 000). The apparent validity and robustness of our estimates highlight the importance of serological data for the characterization of varicella epidemiology, even in the absence of sampling or assay standardization.
Notes: [Bollaerts, K.; Riera-Montes, M.; Verstraeten, T.] P95 Pharmacovigilance & Epidemiol Serv, Koning Leopold 3 Laan 1, B-3001 Leuven, Belgium. [Heininger, U.] Univ Basel, Childrens Hosp, Div Paediat Infect Dis & Vaccinol, CH-4056 Basel, Switzerland. [Hens, N.] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Diepenbeek, Belgium. [Hens, N.] Univ Antwerp, Ctr Hlth Econ Res & Modelling Infect Dis, Antwerp, Belgium. [Hens, N.] Univ Antwerp, Ctr Evaluat Vaccinat, Vaccine & Infect Dis Inst, Antwerp, Belgium. [Souverain, A.] Aixial, 4 Rue Danjou, F-92513 Boulogne, France. [Hartwig, S.] Sanofi Pasteur MSD, 162 Ave Jean Jaures, F-69007 Lyon, France.
URI: http://hdl.handle.net/1942/25718
DOI: 10.1017/S0950268817001546
ISI #: 000414607700003
ISSN: 0950-2688
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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