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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/25708

Title: Validation of a novel imaging approach using multi-slice CT and cone-beam CT to follow-up on condylar remodeling after bimaxillary surgery
Authors: Nicolielo, Laura Ferreira Pinheiro
Van Dessel, Jeroen
Shaheen, Eman
Letelier, Carolina
Codari, Marina
Politis, Constantinus
Lambrichts, Ivo
Jacobs, Reinhilde
Issue Date: 2017
Abstract: The main goal of this study was to introduce a novel three-dimensional procedure to objectively quantify both inner and outer condylar remodelling on preoperative multi-slice computed tomography (MSCT) and postoperative cone-beam computed tomography (CBCT) images. Second, the reliability and accuracy of this condylar volume quantification method was assessed. The mandibles of 20 patients (11 female and 9 male) who underwent bimaxillary surgery were semi-automatically extracted from MSCT/CBCT scans and rendered in 3D. The resulting condyles were spatially matched by using an anatomical landmark-based registration procedure. A standardized sphere was created around each condyle, and the condylar bone volume within this selected region of interest was automatically calculated. To investigate the reproducibility of the method, inter-and intra-observer reliability was calculated for assessments made by two experienced radiologists twice five months apart in a set of ten randomly selected patients. To test the accuracy of the bone segmentation, the inner and outer bone structures of one dry mandible, scanned according to the clinical set-up, were compared with the gold standard, micro-CT. Thirty-eight condyles showed a significant (P<0.05) mean bone volume decrease of 26.4%+/- 11.4% (502.9 mm(3)+/- 268.1mm(3)). No significant effects of side, sex or age were found. Good to excellent (ICC>0.6) intra-and inter-observer reliability was observed for both MSCT and CBCT. Moreover, the bone segmentation accuracy was less than one voxel (0.4mm) for MSCT (0.3 mm +/- 0.2 mm) and CBCT (0.4 mm +/- 0.3 mm), thus indicating the clinical potential of this method for objective follow-up in pathological condylar resorption.
Notes: [Nicolielo, Laura Ferreira Pinheiro; Van Dessel, Jeroen; Shaheen, Eman; Letelier, Carolina; Politis, Constantinus; Jacobs, Reinhilde] Univ Leuven, Fac Med, Dept Imaging & Pathol, OMFS IMPATH Res Grp, Campus Sint Rafael,Kapucijnenvoer 33, BE-3000 Leuven, Belgium. [Nicolielo, Laura Ferreira Pinheiro; Van Dessel, Jeroen; Shaheen, Eman; Letelier, Carolina; Politis, Constantinus; Jacobs, Reinhilde] Univ Hosp Leuven, Maxillofacial Surg Dept, Campus Sint Rafael,Kapucijnenvoer 33, BE-3000 Leuven, Belgium. [Letelier, Carolina] Univ Andes, Dept Oral & Maxillofacial Radiol, Santiago, Chile. [Codari, Marina] IRCCS Policlin San Donato, Unit Radiol, Via Morandi 30, Milan, Italy. [Lambrichts, Ivo] Univ Hasselt, Dept Morphol, Fac Med, Diepenbeek, Belgium. [Jacobs, Reinhilde] Karolinska Inst, Dept Dent Med, Huddinge, Sweden.
URI: http://hdl.handle.net/1942/25708
DOI: 10.1038/ijos.2017.22
ISI #: 000412053800003
ISSN: 1674-2818
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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