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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/25647

Title: Recent versus chronic fine particulate air pollution exposure as determinant of the retinal microvasculature in school children
Authors: Provost, Eline
Int Panis, Luc
Saenen, Nelly D.
Kicinski, Michal
Louwies, Tijs
Vrijens, Karen
De Boever, Patrick
Nawrot, Tim
Issue Date: 2017
Citation: ENVIRONMENTAL RESEARCH, 159, p. 103-110
Abstract: Background: Microvascular changes may represent an underlying mechanism through which exposure to fine particulate matter with a diameter ≤ 2.5 μm (PM2.5) contributes to age-related disease development. We investigated the effect of recent and chronic exposure to PM2.5 on the microcirculation, exemplified by retinal vessel diameters, using repeated measurements in 8- to 12-year-old children. Methods: 221 children (49.1% girls; mean age 9.9 years) were examined repeatedly (25 one, 124 two, and 72 three times) adding up to 489 retinal vessel examinations. Same-day exposure to PM2.5 was measured at school. In addition, recent (same and previous day) and chronic (yearly mean) exposure was modelled at the child's residence using a high-resolution interpolation model. Residential proximity to major roads was also assessed. Changes in retinal vessel diameters associated with recent and chronic exposures were estimated using mixed models, while adjusting for other known covariates such as sex, age, BMI, blood pressure and birth weight. Results: Each 10 μg/m³ increment in same-day exposure to PM2.5 measured at school was associated with 0.35 μm (95% CI: 0.09–0.61 μm) narrower retinal arterioles and 0.35 μm (−0.03 to 0.73 μm) wider venules. Children living 100 m closer to a major road had 0.30 μm (0.05–0.54 μm) narrower arterioles. Conclusions: Blood vessel diameters of the retinal microcirculation of healthy school-aged children respond to same-day PM2.5 exposure. Furthermore, children living closer to major roads had smaller arteriolar diameters. Our results suggest that the microcirculation, with retinal microvasculature as a proxy in this study, is a pathophysiological target for air pollution in children.
Notes: [Provost, Eline B.; Saenen, Nelly D.; Kicinski, Michal; Louwies, Tijs; Vrijens, Karen; De Boever, Patrick; Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, Hasselt, Belgium. [Provost, Eline B.; Panis, Luc Int; Louwies, Tijs; De Boever, Patrick] Flemish Inst Technol Res VITO, Environm Risk & Hlth, Mol, Belgium. [Panis, Luc Int] Hasselt Univ, Sch Mobil, Hasselt, Belgium. [Nawrot, Tim S.] Leuven Univ, Dept Publ Hlth & Primary Care, Leuven, Belgium.
URI: http://hdl.handle.net/1942/25647
Link to publication: https://www.researchgate.net/publication/318928680_Recent_versus_chronic_fine_particulate_air_pollution_exposure_as_determinant_of_the_retinal_microvasculature_in_school_children
DOI: 10.1016/j.envres.2017.07.027
ISI #: 000413280500012
ISSN: 0013-9351
Category: A1
Type: Journal Contribution
Validation: ecoom, 2018
Appears in Collections: Research publications

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