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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/25613

Title: Perception of induced dyspnea in fibromyalgia and chronic fatigue syndrome
Authors: Van Den Houte, Maaike
Bogaerts, Katleen
Van Diest, Ilse
De Bie, Jozef
Persoons, Philippe
Van Oudenhove, Lukas
Van den Bergh, Omer
Issue Date: 2018
Status: In Press
Abstract: Objective: Dyspnea perception is distorted in patients with medically unexplained dyspnea. The goals of this study were 1) to replicate these results in patients with fibromyalgia and/or chronic fatigue syndrome (CFS), and 2) to investigate predictors of distorted symptom perception within the patient group, with a focus on negative affectivity (NA), psychiatric comorbidity and somatic symptom severity. Methods: Seventy-three patients diagnosed with fibromyalgia and/or CFS and 38 healthy controls (HC) completed a rebreathing paradigm, consisting of a baseline (60s of room air), a rebreathing phase (150s, gradually increasing ventilation, partial pressure of CO2 in the blood, and self-reported dyspnea), and a recovery phase (150s of room air). Dyspnea, respiratory flow and FetCO2 levels were measured continuously. Results: Patients reported more dyspnea than HC in the recovery phase (p = 0.039), but no differences between patients and HC were found in the baseline (p = 0.07) or rebreathing phase (p = 0.17). No significant differences between patients and HC were found in physiological reactivity. Within the patient group, the effect in the recovery phase was predicted by somatic symptom severity (p = 0.046), but not by negative affectivity or by the number of psychiatric comorbidities. Conclusion: This study extended earlier findings in patients with medically unexplained dyspnea to patients with fibromyalgia and CFS. This suggests that altered symptom perception is a non-symptom-specific mechanism underlying functional somatic syndromes in general, particularly in patients with high levels of somatic symptom severity . The results are discussed in a predictive coding framework of symptom perception.
Notes: Van den Bergh, O (reprint author), Univ Leuven, KU Leuven, Tiensestr 102, B-3000 Leuven, Belgium, maaike.vandenhoute@kuleuven.be; katleen.bogaerts@kuleuven.be; ilse.vandiest@kuleuven.be; Jozef.DeBie@zol.be; philippe.persoons@kuleuven.be; lukas.vanoudenhove@kuleuven.be; omer.vandenbergh@ppw.kuleuven.be
URI: http://hdl.handle.net/1942/25613
DOI: 10.1016/j.jpsychores.2018.01.007.
ISI #: 000426335100007
ISSN: 0022-3999
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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