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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/25608

Title: Tonically Active α2 Subunit-Containing Glycine Receptors Regulate the Excitability of Striatal Medium Spiny Neurons
Authors: Molchanova, Svetlana M.
Karadurmus, Deniz
Piccart, Elisabeth
Harvey, Robert J.
Rigo, Jean-Michel
Schiffmann, Serge N.
Brône, Bert
Gall, David
Issue Date: 2018
Citation: Frontiers in Molecular Neuroscience, 10 (Art N° 442)
Abstract: Medium spiny neurons (MSNs) of the dorsal striatum represent the first relay of cortico-striato–thalamic loop, responsible for the initiation of voluntary movements and motor learning. GABAergic transmission exerts the main inhibitory control of MSNs. However, MSNs also express chloride-permeable glycine receptors (GlyRs) although their subunit composition and functional significance in the striatum is unknown. Here, we studied the function of GlyRs in MSNs of young adult mice. We show that MSNs express functional GlyRs, with α2 being the main agonist binding subunit. These receptors are extrasynaptic and depolarizing at resting state. The pharmacological inhibition of GlyRs, as well as inactivation of the GlyR α2 subunit gene hyperpolarize the membrane potential of MSNs and increase their action potential firing offset. Mice lacking GlyR α2 showed impaired motor memory consolidation without any changes in the initial motor performance. Taken together, these results demonstrate that tonically active GlyRs regulate the firing properties of MSNs and may thus affect the function of basal ganglia.
URI: http://hdl.handle.net/1942/25608
DOI: 10.3389/fnmol.2017.00442
ISI #: 000419595000002
ISSN: 1662-5099
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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