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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/25589

Title: Interdisciplinary advances towards understanding and enhancing the therapeutic potential of stem cell-based therapies for ischaemic stroke
Authors: Gervois, Pascal
Dillen, Yörg
Vangansewinkel, Tim
Hilkens, Petra
Driesen, Ronald B.
Merckx, Greet
Lo Monaco, Melissa
Ratajczak, Jessica
Bronckaers, Annelies
Lambrichts, Ivo
Wolfs, Esther
Issue Date: 2017
Publisher: Springer International Publishing
Citation: Lapchak, Paul A.; Zhang, John H. (Ed.). Cellular and Molecular Approaches to Regeneration and Repair, Springer International Publishing, p. 21-45
Series/Report: Springer Series in Translational Stroke Research
Abstract: Worldwide, stroke is the second single most common cause of death and is a major cause of permanent disability. Moreover, the highest incidence of these pathologies is observed in the elderly, increasing the socioeconomic burden in an aging population. Current available therapies lead to insufficient functional improvement or are not applicable to all patients. This stresses the urgent need for alternative strategies in treating stroke patients, for example cell-based therapies. These cells showed great preclinical potential although the underlying therapeutic mechanisms, preferential route of administration and most suitable stem cell-subtype are unknown. Mechanisms of action include neuroprotection, cell replacement, neurogenesis, immunomodulation and the promotion of both neuroplasticity and angiogenesis in damaged central nervous system regions. Moreover, stem cells have been genetically engineered to enhance their beneficial effects after transplantation. Additionally, noninvasive imaging can be used to provide detailed spatial and functional information on the donor cell fate and the response of the host microenvironment. This chapter provides an overview of recent advances in (bio-)medical research using or manipulating stem cell-based therapies for ischaemic stroke with a focus on their neuroprotective, neuroregenerative and immunomodulatory properties. Additionally, the use of noninvasive imaging to allow temporospatial evaluation of stem cell fate following transplantation in animal stroke models will be discussed.
URI: http://hdl.handle.net/1942/25589
DOI: 10.1007/978-3-319-66679-2_2
ISBN: 9783319666785
ISSN: 2363-958X
Category: B2
Type: Book Section
Appears in Collections: Research publications

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