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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/2539

Title: Autoimmunity associated with anti-tumor necrosis factor alpha treatment in Crohn's disease: A prospective cohort study
Authors: Vermeire, S.
Noman, M.
Van Assche, G.
Baert, F.
Van Steen, Kristel
Esters, N.
Joossens, S
Bossuyt, X.
Rutgeerts, P.
Issue Date: 2003
Publisher: W B SAUNDERS CO
Citation: GASTROENTEROLOGY, 125(1). p. 32-39
Abstract: Background & Aims: Infliximab therapy is an effective approach to treating Crohn's disease. Development of antinuclear antibodies has been described in patients treated, but the size of the problem and the relationship with autoimmunity have not been investigated. We investigated the occurrence of antinuclear antibodies in 125 consecutive Crohn's disease patients and studied the relationship with symptoms of autoimmunity. Methods: Autoantibodies and clinical data were investigated before and 1, 2, and 3 months after infliximab infusion. If antinuclear antibodies were greater than or equal to1:80, further study of double-stranded DNA, single-stranded DNA, histones, and ENA was performed. Results: Cumulative antinuclear antibody incidence at 24 months was 71 of 125 (56.8%). Almost half of these patients developed antinuclear antibodies after the first infusion, and >75% became antinuclear antibody positive after fewer than 3 infusions. So far, only :15 of 71 patients have become seronegative, after a median of 12 months. Of 43 antinuclear antibody-positive patients who were further subtyped, 14 of 43 (32.6%) had double-stranded DNA, 17 (39.5%) had single-stranded DNA, 9 (20.9%) had antihistone, and 0% were ENA positive. Two patients (both antihistone and double-stranded DNA positive) developed drug-induced lupus without major organ damage, and I developed autoimmune hemolytic anemia. Antinuclear antibodies were associated with the female sex (odds ratio, 3.166; 95% confidence interval, 1.167-8.585; P = 0.024) and with papulosquamous or butterfly rash (odds ratio, 10.016; 95% confidence interval, 1.708-58.725; P = 0.011). Conclusions: The cumulative incidence of antinuclear antibodies was 56.8% after 24 months in this cohort of infliximab-treated Crohn's disease patients. Antinuclear antibodies persisted up to I year after the last infusion, and only a few patients became seronegative. Two patients developed drug-induced lupus erythematosus. Antinuclear antibodies were associated with the female sex and skin manifestations.
Notes: Univ Hosp Gasthuisberg, Gastroenterol Unit, B-3000 Louvain, Belgium. Univ Limburg Ctr, Ctr Stat, Diepenbeek, Belgium. Univ Hosp Gasthuisberg, Med Lab, Louvain, Belgium.Rutgeerts, P, Univ Hosp Gasthuisberg, Gastroenterol Unit, Herestraat 49, B-3000 Louvain, Belgium.
URI: http://hdl.handle.net/1942/2539
DOI: 10.1016/S0016-5085(03)00701-7
ISI #: 000184048000008
ISSN: 0016-5085
Category: A1
Type: Journal Contribution
Validation: ecoom, 2004
Appears in Collections: Research publications

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