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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/25020

Title: Elevated cardiovascular risk factors in Multiple Sclerosis
Authors: Keytsman, Charly
Op 't Eijnde, Bert O.
Hansen, Dominique
Verboven, Kenneth
Wens, Inez
Issue Date: 2017
Citation: Multiple Sclerosis and Related Disorders, 17, p. 220-223
Abstract: Background Multiple sclerosis (MS) is associated with elevated cardiovascular mortality. To prevent this a better understanding of their CVD risk factors and interrelations is necessary. Methods MS patients (n = 52) and healthy controls (HC, n = 24) were matched for age, height, weight, body mass index and physical activity. Body composition, resting blood pressure (BP), resting heart rate (HR), glucose tolerance, HbA1c, blood lipids (HDL, LDL, total cholesterol, triglyceride concentrations) and c-reactive protein concentrations were analyzed. Regression analyses identified independent CVD risk factors and their interrelations in MS. Results In MS and compared to HC, fat mass (25.1 ± 1.2 kg vs. 17.9 ± 1 kg), fat percentage (33.8 ± 1.2% vs. 28.4 ± 1.5%), systolic (130 ± 1.8 mmHg vs. 120 ± 2.9 mmHg) and diastolic (79 ± 1.1 mmHg vs. 71 ± 1.9 mmHg) BP, resting HR (72 ± 1.4 bpm vs. 60 ± 2 bpm), blood triglycerides (113.8 ± 8.6 mg/dl vs. 98.2 ± 17.4 mg/dl), fasting (13.5 ± 2.9 mU/l vs. 7.2 ± 0.8 mU/l) and 2 h insulin (71.9 ± 12.5 mU/l vs. 35.8 ± 8.1 mU/l), 2 h glucose (6.3 ± 0.5 mmol/l vs. 4.8 ± 0.5 mmol/l) and HOMA index (3.7 ± 1.1 vs. 1.7 ± 0.2) were significantly (p < 0.05) elevated. Total cholesterol, blood HDL and LDL concentrations did nog differ between groups (p < 0.05). Regression analyses indicated that MS is independently associated with elevated fat mass/percentage, systolic and diastolic BP and HR and in MS fat mass appears to be an independent contributor of the other measured CVD risk factors in MS. Conclusion Persons with MS have an increased risk for CVD and fat mass appears to be an important risk factor. Therefore, normalizing whole body fat should be an essential part of MS treatment.
Notes: Keytsman, C (reprint author), Hasselt Univ, REVAL Rehabil Ctr, Biomed Res Inst BIOMED, Agoralaan Bldg A, B-3590 Diepenbeek, Belgium. charly.keytsman@uhasselt.be
URI: http://hdl.handle.net/1942/25020
DOI: 10.1016/j.msard.2017.08.011
ISI #: 000414816700043
ISSN: 2211-0348
Category: A1
Type: Journal Contribution
Validation: ecoom, 2018
Appears in Collections: Research publications

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