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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24966

Title: Circulating Follicular Regulatory T Cells in Autoimmune Diseases and Their Waning in Multiple Sclerosis
Authors: Dhaeze, Tessa
Hellings, Niels
Issue Date: 2016
Citation: CRITICAL REVIEWS IN IMMUNOLOGY, 36(6), p. 511-522
Abstract: Follicular regulatory T cells (T(FR)s) are a subset of regulatory T cells that reside in the secondary lymphoid organs and participate in controlling the germinal center (GC) response. The GC response forms the basis of adaptive immunity to foreign protein antigens. In autoimmune diseases, hyperreactivity to self-antigens occurs that may result from an aberrant control of the GC response. T-FR dysfunctionality may be one of the factors contributing to this breakdown of self-tolerance. In this review, we discuss how the investigation of circulating TFRs can help us understand their relative contribution to autoimmune-mediated disease processes. Multiple sclerosis is taken as a classical example of autoimmune disease.
Notes: [Dhaeze, Tessa] Univ Montreal, Hosp Ctr CRCHUM, Res Ctr, 900 Rue St Denis, Montreal, PQ H2X 0A9, Canada. [Dhaeze, Tessa] Univ Montreal, Dept Neurosci, Fac Med, 900 Rue St Denis, Montreal, PQ H2X 0A9, Canada. [Dhaeze, Tessa; Hellings, Niels] Hasselt Univ, Biomed Res Inst, Agoralaan Bldg C, B-3590 Diepenbeek, Belgium. [Dhaeze, Tessa; Hellings, Niels] Transnatl Univ Limburg, Sch Life Sci, Agoralaan Bldg C, B-3590 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/24966
DOI: 10.1615/CritRevImmunol.2017019850
ISI #: 000408490100004
ISSN: 1040-8401
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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