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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24960

Title: Salivary DNA Methylation Profiling: Aspects to Consider for Biomarker Identification
Authors: Langie, Sabine A. S.
Moisse, Matthieu
Declerck, Ken
Koppen, Gudrun
Godderis, Lode
Vanden Berghe, Wim
Drury, Stacy
De Boever, Patrick
Issue Date: 2017
Publisher: WILEY
Abstract: Is it not more comfortable to spit saliva in a tube than to be pricked with a needle to draw blood to analyse your health and disease risk? Many patients, study participants and (parents of) young children undoubtedly prefer non-invasive and convenient procedures. Such procedures increase compliance rates especially for longitudinal prospective studies. Saliva is an attractive biofluid providing good quality DNA to study epigenetic mechanisms underlying disease across development. In this MiniReview, we will describe the different applications of saliva in the field of epigenetics, focusing on genomewide methylation analysis. Advantages of the use of saliva and its comparability with blood will be discussed, as will the challenges in data processing and interpretation. Knowledge gaps will be identified and suggestions given on how to improve the analysis, making saliva 'the' biofluid of choice for future biomarker initiatives in many different epidemiological and public health studies.
Notes: [Langie, Sabine A. S.; Koppen, Gudrun; De Boever, Patrick] Flemish Inst Technol Res VITO, Environm Risk & Hlth Unit, Mol, Belgium. [Langie, Sabine A. S.; De Boever, Patrick] Hasselt Univ, Fac Sci, Diepenbeek, Belgium. [Moisse, Matthieu] Katholieke Univ Leuven, VIB Vesalius Res Ctr, Leuven, Belgium. [Declerck, Ken; Vanden Berghe, Wim] Univ Antwerp, Dept Biomed Sci, Lab Prot Chem Prote & Epigenet Signaling, Antwerp, Belgium. [Godderis, Lode] Katholieke Univ Leuven, Dept Publ Hlth & Primary Care, Ctr Environm & Hlth, Leuven, Belgium. [Godderis, Lode] IDEWE, External Serv Prevent & Protect Work, Heverlee, Belgium. [Drury, Stacy] Tulane Univ, Inst Brain, New Orleans, LA 70118 USA. [Drury, Stacy] Tulane Univ, Sch Med, Dept Psychiat & Behav Sci, 1430 Tulane Ave, New Orleans, LA 70112 USA.
URI: http://hdl.handle.net/1942/24960
DOI: 10.1111/bcpt.12721
ISI #: 000411036200011
ISSN: 1742-7835
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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