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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24938

Title: Cord blood eicosanoid signatures and newborn gestational age
Authors: Gouveia-Figueira, Sandra
Martens, Dries S.
Nawrot, Tim S.
Nording, Malin L.
Issue Date: 2017
Status: In Press
Abstract: Beyond prostaglandins, the function of eicosanoids and other oxylipins in pregnancy and labor is poorly understood. In contrast to earlier work focusing on preterm infants, we investigated how oxylipin levels in newborns (measured in cord blood) vary during the last weeks of pregnancy in 190 mother-newborns (≥37 weeks of gestation) of the ENVIRONAGE birth cohort, Belgium. We found increased levels of PGE2 (p = 0.003), PGF2α (p = 0.042), 8,9-DHET (p = 0.037), 11-HETE (p = 0.034), and 15-HETrE (p = 0.008) associated with full term pregnancy compared to early term labor. Furthermore, late vs early term was associated with increased levels of PGE2 (p = 0.012) and TXB2 (p = 0.033), while late vs full term was associated with decreased levels of 14,15-DHET (p = 0.029), 11,12-DHET (p = 0.033), and 5-HETE (p = 0.045). To summarize, nine eicosanoids, derived via three enzymatic pathways, were significantly associated with gestational age. Eight of these were derived from arachidonic acid, and one from dihomo-γ-linolenic acid.
Notes: Nording, ML (reprint author), Umea Univ, Dept Chem, S-90187 Umea, Sweden malin.nording@umu.se
URI: http://hdl.handle.net/1942/24938
DOI: 10.1016/j.prostaglandins.2017.07.003
ISI #: 000418729100017
ISSN: 1098-8823
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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