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|Title: ||Natriuretic peptides in the control of lipid metabolism and insulin sensitivity|
|Authors: ||Verboven, Kenneth|
Jocken, Johan W.E.
Blaak, Ellen E.
|Issue Date: ||2017|
|Citation: ||Obesity Reviews, 18 (11), p.1243-1259|
|Status: ||Early View|
|Abstract: ||Natriuretic peptides have long been known for their cardiovascular function. However,a growing body of evidence emphasizes the role of natriuretic peptides in human
substrate and energy metabolism, thereby connecting the heart with several
insulin-sensitive organs like adipose tissue, skeletal muscle and liver. Obesity may
be associated with an impaired regulation of the natriuretic peptide system, also indicated
as a natriuretic handicap. Evidence points towards a contribution of this
natriuretic handicap to the development of obesity, type 2 diabetes mellitus and
cardiometabolic complications, although the causal relationship is not fully
understood. Nevertheless, targeting the natriuretic peptide pathway may improve
metabolic health in obesity and type 2 diabetes mellitus. This review will focus
on current literature regarding the metabolic roles of natriuretic peptides with
emphasis on lipid metabolism and insulin sensitivity. Furthermore, it will be
discussed how exercise and lifestyle intervention may modulate the natriuretic
peptide-related metabolic effects.|
|Notes: ||Blaak, EE (reprint author), Maastricht Univ, Med Ctr, NUTRIM Sch Nutr & Translat Res Metab, Dept Human Biol, POB 616, NL-6200 MD Maastricht, Netherlands.
|ISI #: ||000412643600002|
|Type: ||Journal Contribution|
|Appears in Collections: ||Research publications|
Files in This Item:
|Published version||327.58 kB||Adobe PDF|
|Peer-reviewed author version||561.97 kB||Adobe PDF|
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