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|Title: ||Contra-lateral bone loss at the distal radius in postmenopausal women after a distal radius fracture: A two-year follow-up HRpQCT study|
|Authors: ||de Jong, Joost J. A.|
Arts, Jacobus J. C.
Willems, Paul C.
Bours, Sandrine P. G.
Bons, Judith P. A.
Menheere, Paul P. C. A.
van Rietbergen, Bert
Geusens, Piet P.
van den Bergh, Joop P. W.
|Issue Date: ||2017|
|Publisher: ||ELSEVIER SCIENCE INC|
|Citation: ||BONE, 101, p. 245-251|
|Abstract: ||Opposite to the fracture side, bone mineral density (BMD) measured by DXA at the contra-lateral side does not change after a distal radius fracture. However, it is unknown if also bone micro-architecture and strength at the contralateral side are unaffected. Therefore, the aim of this study was to assess BMD, micro-architecture and bone mechanical properties at the contra-lateral side during two years follow-up after a distal radius fracture using high resolution peripheral quantitative computed tomography (HRpQCT). The contra-lateral distal radius of 15 postmenopausal women (mean age 64 8 years) with a distal radius fracture treated by cast immobilization was scanned by HRpQCT at baseline, 3 months and 2 years post-fracture. BMD and cortical and trabecular micro architecture were measured and biomechanical parameters were estimated using micro finite element analysis (mu FEA). Additionally, markers of bone resorption and formation were measured at each visit. Bone parameters and turnover markers across the three visits were analysed using a linear mixed-effect model with Bonferroni correction. Two years post-fracture, a significant decrease from baseline was found in cortical BMD (-4.2%, p < 0.001), failure load (-6.1%, p = 0.001), stiffness in compression (5.7%, p = 0.003) and bending (-6.4%, p = 0.008), and bone formation (-47.6%, p = 0.010). No significant changes from baseline were observed in total and trabecular BMD, nor in cortical or trabecular micro-architecture and neither in bone resorption. Results were similar between patients with or without adequate anti-osteoporosis drug treatment. We found a significant decline in BMD in the cortical but not the trabecular region, and a reduction in bone strength and stiffness at the contra-lateral side two years after a distal radius fracture. These changes exceeded the changes that may be expected due to aging, even in the presence of adequate anti-osteoporosis treatment. (C) 2017 Elsevier Inc. All rights reserved.|
|Notes: ||[de Jong, Joost J. A.; van den Bergh, Joop P. W.] Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Med Ctr, Maastricht, Netherlands. [de Jong, Joost J. A.; Bours, Sandrine P. G.; Geusens, Piet P.; van den Bergh, Joop P. W.] Maastricht Univ, Med Ctr, Dept Rheumatol, POB 5800, NL-6202 AZ Maastricht, Netherlands. [Arts, Jacobus J. C.; Willems, Paul C.; Geusens, Piet P.] Maastricht Univ, Med Ctr, CAPHRI Sch Publ Hlth & Primary Care, Maastricht, Netherlands. [Arts, Jacobus J. C.; Willems, Paul C.] Maastricht Univ, Med Ctr, Dept Orthopaed Surg, Maastricht, Netherlands. [Arts, Jacobus J. C.; van Rietbergen, Bert] Eindhoven Univ Technol, Fac Biomed Engn, Sect Orthopaed Biomech, Eindhoven, Netherlands. [Bons, Judith P. A.; Menheere, Paul P. C. A.] Maastricht Univ, Med Ctr, Cent Diagnost Lab, Maastricht, Netherlands. [Geusens, Piet P.; van den Bergh, Joop P. W.] Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. [van den Bergh, Joop P. W.] VieCuri Med Ctr Venlo, Dept Internal Med, Venlo, Netherlands.|
|ISI #: ||000404319300030|
|Type: ||Journal Contribution|
|Appears in Collections: ||Research publications|
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