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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24458

Title: Advanced glycation end products (AGEs) and cardiovascular dysfunction: focus on high molecular weight AGEs
Authors: Deluyker, Dorien
Evens, Lize
Bito, Virginie
Issue Date: 2017
Publisher: SPRINGER WIEN
Citation: AMINO ACIDS, 49(9), p. 1535-1541
Abstract: Advanced glycation end products (AGEs) are a group of proteins and lipids becoming glycated and oxidized after persistent contact with reducing sugars or short-chain aldehydes with amino group and/or high degree of oxidative stress. The accumulation of AGEs in the body is a natural process that occurs with senescence, when the turnover rate of proteins is reduced. However, increased circulating AGEs have been described to arise at early lifetime and are associated with adverse outcome and survival, in particular in settings of cardiovascular diseases. AGEs contribute to the development of cardiac dysfunction by two major mechanisms: cross-linking of proteins or binding to their cell surface receptor. Recently, growing evidence shows that high-molecular weight AGEs (HMW-AGEs) might be as important as the characterized low-molecular weight AGEs (LMW-AGEs). Here, we point out the targets of AGEs in the heart and the mechanisms that lead to heart failure with focus on the difference between LMW-AGEs and the less characterized HMW-AGEs. As such, this review is a compilation of relevant papers in the form of a useful resource tool for researchers who want to further investigate the role of HMW-AGEs on cardiac disorders and need a solid base to start on this specific topic.
Notes: [Deluyker, Dorien; Evens, Lize; Bito, Virginie] Hasselt Univ, Biomed Res Inst BIOMED, Martelarenlaan 42, B-3500 Hasselt, Belgium. [Bito, Virginie] Hasselt Univ, Biomed Res Inst BIOMED, Physiol, Agoralaan Bldg C, B-3590 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/24458
DOI: 10.1007/s00726-017-2464-8
ISI #: 000407922900006
ISSN: 0939-4451
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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