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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24456

Title: Disease severity in patients with visceral leishmaniasis is not altered by co-infection with intestinal parasites
Authors: Tajebe, Fitsumbrhan
Getahun, Mulusew
Adem, Emebet
Hailu, Asrat
Lemma, Mulualem
Fikre, Helina
Raynes, John
Tamiru, Aschalew
Mulugeta, Zemenay
Diro, Ermias
Toulza, Frederic
Shkedy, Ziv
Ayele, Tadesse
Modolell, Manuel
Munder, Markus
Mueller, Ingrid
Takele, Yegnasew
Kropf, Pascale
Issue Date: 2017
Publisher: PUBLIC LIBRARY SCIENCE
Citation: PLOS NEGLECTED TROPICAL DISEASES, 11(7), p. 1-16
Abstract: Visceral leishmaniasis (VL) is a neglected tropical disease that affects the poorest communities and can cause substantial morbidity and mortality. Visceral leishmaniasis is characterized by the presence of Leishmania parasites in the spleen, liver and bone marrow, hepatosplenomegaly, pancytopenia, prolonged fever, systemic inflammation and low body mass index (BMI). The factors impacting on the severity of VL are poorly characterized. Here we performed a cross-sectional study to assess whether co-infection of VL patients with intestinal parasites influences disease severity, assessed with clinical and haematological data, inflammation, cytokine profiles and BMI. Data from VL patients was similar to VL patients co-infected with intestinal parasites, suggesting that co-infection of VL patients with intestinal parasites does not alter disease severity.
Notes: [Tajebe, Fitsumbrhan; Getahun, Mulusew] Univ Gondar, Dept Immunol & Mol Biol, Gondar, Ethiopia. [Adem, Emebet; Fikre, Helina; Tamiru, Aschalew; Mulugeta, Zemenay; Diro, Ermias; Takele, Yegnasew] Univ Gondar, Leishmaniasis Res & Treatment Ctr, Gondar, Ethiopia. [Hailu, Asrat] Univ Addis Ababa, Dept Microbiol Immunol & Parasitol, Addis Ababa, Ethiopia. [Lemma, Mulualem; Diro, Ermias] Univ Gondar, Dept Internal Med, Gondar, Ethiopia. [Raynes, John] London Sch Hyg & Trop Med, Dept Immunol & Infect, London, England. [Toulza, Frederic] Kings Coll London, Fac Life Sci, Dept Haematol Med, London, England. [Shkedy, Ziv; Ayele, Tadesse] Univ Hasselt, Dept Math & Stat, Hasselt, Belgium. [Modolell, Manuel] Max Planck Inst Immunobiol & Epigenet, Dept Cellular Immunol, Freiburg, Germany. [Munder, Markus] Univ Med Ctr Mainz, Dept Med Hematol Oncol & Pneumol 3, Mainz, Germany. [Mueller, Ingrid; Takele, Yegnasew; Kropf, Pascale] Imperial Coll London, Dept Med, London, England. [Getahun, Mulusew] Ethiopian Publ Hlth Inst, Addis Ababa, Ethiopia.
URI: http://hdl.handle.net/1942/24456
DOI: 10.1371/journal.pntd.0005727
ISI #: 000408057300039
ISSN: 1935-2727
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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