www.uhasselt.be
DSpace

Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24455

Title: CHADS(2) risk score and rate of stroke or systemic embolism and major bleeding in patients with non-valvular atrial fibrillation receiving non-vitamin K antagonist oral anticoagulants
Authors: Van Mieghem, Walter
Lancellotti, Patrizio
Issue Date: 2017
Publisher: TAYLOR & FRANCIS LTD
Citation: ACTA CARDIOLOGICA, 72(4), p. 390-396
Abstract: Randomized trials showed non-inferior or superior results of the non-vitamin K antagonist oral anticoagulants (NOACs) compared with warfarin in patients with non-valvular atrial fibrillation (AF). Despite the absence of direct head-to-head comparisons between the different NOACs, certain molecules have been proposed for subgroups of patients based mainly on the perception of different bleeding risks. The CHADS(2) score has been uniformly used in the inclusion criteria of these studies and shared similar risk factors as the haemorrhagic risk score HAS-BLED. The aim of the present report was to highlight the relationships between CHADS(2) score and the rate of stroke or systemic embolism, and the rate of major bleeding in patients with AF on treatment with NOACs. Overall, in all the available randomized studies, a fairly good continuous relationship was observed between the CHADS(2) risk score and the rate of stroke or systemic embolism, and the rate of major bleeding in the different studies. Larger registries are needed to confirm this hypothesis.
Notes: [Van Mieghem, Walter] Univ Hasselt, Hasselt, Belgium. [Lancellotti, Patrizio] Univ Liege Hosp, GIGA Cardiovasc Sci, Dept Cardiol, Heart Valve Clin,CHU Sart Tilman, Liege, Belgium. [Lancellotti, Patrizio] Anthea Hosp, Grp Villa Maria Care & Res, Bari, Italy.
URI: http://hdl.handle.net/1942/24455
DOI: 10.1080/00015385.2017.1327248
ISI #: 000408014600004
ISSN: 0001-5385
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

Files in This Item:

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.