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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24446

Title: Neonatal exposure to environmental pollutants and placental mitochondrial DNA content: A multi-pollutant approach
Authors: Vriens, Annette
Nawrot, Tim S.
Baeyens, Willy
Den Hond, Elly
Bruckers, Liesbeth
Covaci, Adrian
Croes, Kim
De Craemer, Sam
Govarts, Eva
Lambrechts, Nathalie
Loots, Ilse
Nelen, Vera
Peusens, Martien
De Henauw, Stefaan
Schoeters, Greet
Plusquin, Michelle
Issue Date: 2017
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Citation: ENVIRONMENT INTERNATIONAL, 106, p. 60-68
Abstract: Background: Placental mitochondrial DNA (mtDNA) content can be indicative of oxidative damage to the placenta during fetal development and is responsive to external stressors. In utero exposure to environmental pollutants that may influence placental mtDNA needs further exploration. Objectives: We evaluated if placental mtDNA content is altered by environmental pollution in newborns and identified pollutants independently associated to alterations in placental mtDNA content. Methods: mtDNA content was measured in placental tissue of 233 newborns. Four perfluoroalkyl compounds and nine organochlorine compounds were quantified in cord blood plasma samples and six toxic metals in whole cord blood. We first applied a LASSO (least absolute shrinkage and selection operator) penalized regression model to identify independent associations between environmental pollutants and placental mtDNA content, without penalization of several covariates. Then adjusted estimates were obtained using an ordinary least squares (OLS) regression model evaluating the pollutants' association with placental mtDNA content, adjusted for several covariates. Results: Based on LASSO penalized regression, oxychlordane, p,p'-dichlorodiphenyldichloroethylene, beta-hexachlorocyclohexane, perfluorononanoic acid, arsenic, cadmium and thallium were identified to be independently associated with placental mtDNA content. The OLS model showed a higher placental mtDNA content of 2.71% (95% CI: 0.3 to 5.2%; p = 0.03) and 1.41% (0.1 to 2.8%, p = 0.04) for a 25% concentration increase of respectively cord blood beta-hexachlorocyclohexane and arsenic. For a 25% concentration increase of cord blood thallium, a 4.88% lower placental mtDNA content (95% CI: -9.1 to -0.5%, p = 0.03) was observed. Conclusion: In a multi-pollutant approach, low fetal exposure levels of environmental organic and inorganic pollutants might compromise placental mitochondrial function as exemplified in this study by alterations in mtDNA content.
Notes: [Vriens, Annette; Nawrot, Tim S.; Peusens, Martien; Plusquin, Michelle] Hasselt Univ, Ctr Environm Sci, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium. [Nawrot, Tim S.] Leuven Univ, Sch Publ Hlth Occupat & Environm Med, Leuven, Belgium. [Baeyens, Willy; Bruckers, Liesbeth; Croes, Kim; De Craemer, Sam] Vrije Univ Brussel, Dept Analyt & Environm Chem, Brussels, Belgium. [Den Hond, Elly; Nelen, Vera] Prov Inst Hyg, Antwerp, Belgium. [Bruckers, Liesbeth] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Diepenbeek, Belgium. [Covaci, Adrian] Univ Antwerp, Toxicol Ctr, Antwerp, Belgium. [Govarts, Eva; Lambrechts, Nathalie; Schoeters, Greet] Flemish Inst Technol Res VITO, Environm Risk & Hlth, Mol, Belgium. [Loots, Ilse] Univ Antwerp, Fac Social Sci, Antwerp, Belgium. [Loots, Ilse] Univ Antwerp, IMDO Inst, Antwerp, Belgium. [De Henauw, Stefaan] Univ Ghent, Dept Publ Hlth, Ghent, Belgium. [De Henauw, Stefaan] Univ Ghent, Dept Food Safety & Food Qual, Ghent, Belgium.
URI: http://hdl.handle.net/1942/24446
DOI: 10.1016/j.envint.2017.05.022
ISI #: 000406175300008
ISSN: 0160-4120
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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