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|Title: ||Mother's Pre-pregnancy BMI and Placental Candidate miRNAs: Findings from the ENVIRONAGE Birth Cohort|
|Authors: ||Tsamou, Maria|
Martens, Dries S.
Nawrot, Tim S.
|Issue Date: ||2017|
|Publisher: ||NATURE PUBLISHING GROUP|
|Citation: ||SCIENTIFIC REPORTS, 7, p. 1-11 (Art N° 5548)|
|Abstract: ||There is increasing evidence that the predisposition for development of chronic diseases arises at the earliest times of life. In this context, maternal pre-pregnancy weight might modify fetal metabolism and the child's predisposition to develop disease later in life. The aim of this study is to investigate the association between maternal pre-pregnancy body mass index (BMI) and miRNA alterations in placental tissue at birth. In 211 mother-newborn pairs from the ENVIRONAGE birth cohort, we assessed placental expression of seven miRNAs important in crucial cellular processes implicated in adipogenesis and/or obesity. Multiple linear regression models were used to address the associations between pre-pregnancy BMI and placental candidate miRNA expression. Maternal pre-pregnancy BMI averaged (+/- SD) 23.9 (+/- 4.1) kg/m(2). In newborn girls ( not in boys) placental miR-20a, miR-34a and miR-222 expression was lower with higher maternal pre-pregnancy BMI. In addition, the association between maternal pre-pregnancy BMI and placental expression of these miRNAs in girls was modified by gestational weight gain. The lower expression of these miRNAs in placenta in association with pre-pregnancy BMI, was only evident in mothers with low weight gain (< 14 kg). The placental expression of miR-20a, miR-34a, miR-146a, miR-210 and miR-222 may provide a sex-specific basis for epigenetic effects of pre-pregnancy BMI.|
|Notes: ||[Tsamou, Maria; Martens, Dries S.; Winckelmans, Ellen; Madhloum, Narjes; Cox, Bianca; Nawrot, Tim S.; Vrijens, Karen] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium. [Gyselaers, Wilfried] East Limburg Hosp, Dept Obstet, Genk, Belgium. [Nawrot, Tim S.] Katholieke Univ Leuven, Leuven Univ, Environm & Hlth Unit, Dept Publ Hlth, Leuven, Belgium.|
|ISI #: ||000405675400028|
|Type: ||Journal Contribution|
|Appears in Collections: ||Research publications|
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