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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24430

Title: Prognostic value of clinical and electrodiagnostic parameters at time of diagnosis in patients with amyotrophic lateral sclerosis
Authors: Reniers, Wendeline
Schrooten, Maarten
Claeys, Kristl G.
Tilkin, Petra
D'Hondt, Ann
Van Reijen, Dimphna
Couwelier, Goedele
Lamaire, Nikita
Robberecht, Wim
Fieuws, Steffen
Van Damme, Philip
Issue Date: 2017
Abstract: Objective: To assess the added prognostic value of the aggregated clinical and electrodiagnostic data, which define a given diagnostic category according to the Awaji or revised El Escorial criteria at time of diagnosis in patients with amyotrophic lateral sclerosis (ALS). Methods: Clinical signs and electrodiagnostic test results were collected at time of diagnosis in 396 patients with ALS between January 2009 and January 2016. Significant predictors of prognosis were identified using a univariate model, and later combined in a multivariate Cox regression model. Results: Known factors associated with reduced survival included older age at onset, shorter diagnostic delay, higher ALSFRS-R slope and presence of C9orf72 mutation (all p<0.05). Diagnostic category according to Awaji (p<0.0001) or to revised El Escorial (p=0.0177) criteria, definite ALS according to Awaji (p<0.0001) or to revised El Escorial (p=0.0343) and number of regions with LMN involvement (p<0.0001) were all associated with shorter survival. Discussion: Clinical and electrodiagnostic data at time of diagnosis provide additional prognostic information compared to other known prognostic factors. Diagnostic category according to Awaji and the extensiveness of LMN involvement contain the most additional value.
Notes: [Reniers, Wendeline; Schrooten, Maarten; Claeys, Kristl G.; Tilkin, Petra; D'Hondt, Ann; Van Reijen, Dimphna; Couwelier, Goedele; Lamaire, Nikita; Van Damme, Philip] Univ Hosp, Neurol Dept, Campus Gasthuisberg,Herestr 49, B-3000 Leuven, Belgium. [Claeys, Kristl G.; Robberecht, Wim; Van Damme, Philip] Univ Leuven, KU Leuven, Dept Neurosci Expt Neurol, Leuven, Belgium. [Claeys, Kristl G.; Robberecht, Wim; Van Damme, Philip] Leuven Res Inst Neurosci & Dis LIND, Leuven, Belgium. [Van Damme, Philip] VIB, Ctr Brain & Dis Res, Lab Neurobiol, Leuven, Belgium. [Fieuws, Steffen] Univ Leuven, KU Leuven, I BioStat, Dept Publ Hlth & Primary Care, Leuven, Belgium. [Fieuws, Steffen] Univ Hasselt, Leuven, Belgium.
URI: http://hdl.handle.net/1942/24430
DOI: 10.1080/21678421.2017.1288254
ISI #: 000405584600004
ISSN: 2167-8421
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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