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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24429

Title: Nebulized Liposomal Amphotericin B for Treatment of Pulmonary Infection Caused by Hormographiella aspergillata: Case Report and Literature Review
Authors: Godet, Cendrine
Cateau, Estelle
Rammaert, Blandine
Grosset, Marine
Le Moal, Gwenael
Beraud, Guillaume
Martellosio, Jean Philippe
Iriart, Xavier
Cadranel, Jacques
Roblot, France
Issue Date: 2017
Publisher: SPRINGER
Citation: MYCOPATHOLOGIA, 182(7-8), p. 709-713
Abstract: Invasive fungal infection is a serious complication following allogeneic hematopoietic stem cell transplantation. Pulmonary infection due to Hormographiella aspergillata is an uncommon condition associated with a high mortality rate. The susceptibility of H. aspergillata to available antifungal agents is not well established. We report for the first time a case of H. aspergillata lung infection that responded poorly to conventional treatment with liposomal amphotericin B (LAmB; 3 mg kg(-1) of body weight per day) with renal damage at higher posology (5 mg kg(-1) of body weight per day), but improved rapidly after addition of nebulized LAmB to intravenous LAmB (3 mg kg(-1) of body weight per day). Successful treatment of our patient using nebulized LAmB would be worth evaluating in cases refractory to standard treatment or when the reference treatment may not be extended due to interaction or side effects.
Notes: [Godet, Cendrine; Rammaert, Blandine; Le Moal, Gwenael; Beraud, Guillaume; Martellosio, Jean Philippe; Roblot, France] CHU Poitiers, Serv Malad Infect & Trop, F-86000 Poitiers, France. [Cateau, Estelle; Rammaert, Blandine; Roblot, France] Univ Poitiers, Fac Med & Pharm, 6 Rue Miletrie, Poitiers, France. [Cateau, Estelle; Roblot, France] CHU Poitiers, Lab Parasitol Mycol, F-86000 Poitiers, France. [Rammaert, Blandine] INSERM, U1070, 6 Rue Miletrie, Poitiers, France. [Beraud, Guillaume] Univ Droit & Sante Lille 2, EA2694, Lille, France. [Beraud, Guillaume] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Hasselt, Belgium. [Iriart, Xavier] CHU Toulouse, Serv Parasitol Mycol, Toulouse, France. [Iriart, Xavier] Univ Toulouse, Ctr Physiopathol Toulouse Purpan, CNRS, INSERM,UMR U1043,UMR 5282, Toulouse, France. [Cadranel, Jacques] Hop Tenon, AP HP, Serv Pneumo, Paris, France. [Cadranel, Jacques] UPMC Univ Paris 06, Sorbonne Univ, F-0675970 Paris, France. [Godet, Cendrine] CHU Poitiers, Serv Malad Infect & Trop, F-86021 Poitiers, France.
URI: http://hdl.handle.net/1942/24429
DOI: 10.1007/s11046-017-0117-9
ISI #: 000405029300011
ISSN: 0301-486X
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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