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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24424

Title: Short-term air pollution exposure decreases lung function: a repeated measures study in healthy adults
Authors: Panis, Luc Int
Provost, Eline B.
Cox, Bianca
Louwies, Tijs
Laeremans, Michelle
Standaert, Arnout
Dons, Evi
Holmstock, Luc
Nawrot, Tim
De Boever, Patrick
Issue Date: 2017
Citation: ENVIRONMENTAL HEALTH, 16, p. 1-7 (Art N° 60)
Abstract: Background: Daily changes in ambient concentrations of particulate matter, nitrogen oxides and ozone are associated with increased cardiopulmonary morbidity and mortality, with the lungs and their function being a vulnerable target. Methods: To evaluate the association between daily changes in air pollution and lung function in healthy adults we obtained annual lung function measurements from a routine worker health surveillance program not designed for research purposes. Forced Vital Capacity (FVC), Forced Expiratory Volume in the first second (FEV1), FEV1/FVC and Peak Expiratory flow (PEF) from a cohort of 2449 employees were associated with daily measurements of PM10, NO2 and ozone at a nearby monitoring station in the North of Belgium. Repeated measures were available for the period 2011-2015. Results: The mean (SD) PM10 concentration on the day of the lung function test was 24.9 (15.5) mu g/m(3). A 10 mu g PM10/m(3) increase on the day of the clinical examination was associated with a 18.9 ml lower FVC (95% CI: -27.5 to -10.3, p < 0.0001), 12.8 ml lower FEV1 (-19.1 to -6.5; p < 0.0001), and a 51.4 ml/s lower PEF (-75.0 to -27.0; p < 0. 0001). The FEV1/FVC-ratio showed no associations. An increase of 10 aegNO2/m3 was associated with a reduction in PEF (-66.1 ml/s (-106.6 to -25.6; p < 0.001)) on the day of the examination. Conclusions: We found negative associations between daily variations in ambient air pollution and FVC, FEV1 and PEF in healthy adults.
Notes: [Panis, Luc Int; Provost, Eline B.; Louwies, Tijs; Laeremans, Michelle; Standaert, Arnout; Dons, Evi; De Boever, Patrick] Flemish Inst Technol Res VITO, Boeretang 200, B-2400 Mol, Belgium. [Panis, Luc Int; Laeremans, Michelle] Hasselt Univ, Transportat Res Inst, Diepenbeek, Belgium. [Provost, Eline B.; Cox, Bianca; Louwies, Tijs; Dons, Evi; Nawrot, Tim; De Boever, Patrick] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium. [Holmstock, Luc] SCK CEN, Belgian Nucl Res Ctr, Mol, Belgium. [Nawrot, Tim] Leuven Univ, KU Leuven, Dept Publ Hlth, Leuven, Belgium.
URI: http://hdl.handle.net/1942/24424
DOI: 10.1186/s12940-017-0271-z
ISI #: 000403640700003
ISSN: 1476-069X
Category: A1
Type: Journal Contribution
Validation: ecoom, 2018
Appears in Collections: Research publications

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