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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24417

Title: The Phenotype of Patients with a Recent Fracture: A Literature Survey of the Fracture Liaison Service
Authors: Vranken, Lisanne
Wyers, Caroline E.
van den Bergh, Joop P. W.
Geusens, Piet P.M.M.
Issue Date: 2017
Publisher: SPRINGER
Citation: CALCIFIED TISSUE INTERNATIONAL, 101(3), p. 248-258
Abstract: The aetiology of fractures in patients aged 50 years and older is multifactorial, and includes bone- and fall-related risks. The Fracture Liaison Service (FLS) is recommended to identify patients with a recent fracture and to evaluate their subsequent fracture risk, in order to take measures to decrease the risk of subsequent fractures in patients with a high risk phenotype. A literature survey was conducted to describe components of the bone- and fall-related phenotype of patients attending the FLS. Components of the patient phenotype at the FLS have been reported in 33 studies. Patient selection varied widely in terms of patient identification, selection, and FLS attendance. Consequently, there was a high variability in FLS patient characteristics, such as mean age (64-80 years), proportion of men (13-30%), and fracture locations (2-51% hip, < 1-41% vertebral, and 49-95% non-hip, non-vertebral fractures). The studies also varied in the risk evaluation performed. When reported, there was a highly variability in the percentage of patients with osteoporosis (12-54%), prevalent vertebral fractures (20-57%), newly diagnosed contributors to secondary osteoporosis and metabolic bone disorders (3-70%), and fall-related risk factors (60-84%). In FLS literature, we found a high variability in patient selection and risk evaluation, resulting in a highly variable phenotype. In order to specify the bone- and fall related phenotypes at the FLS, systematic studies on the presence and combinations of these risks are needed.
Notes: [Vranken, Lisanne; Wyers, Caroline E.; van den Bergh, Joop P. W.] VieCuri Med Ctr, Dept Internal Med, POB 1926, NL-5900 BX Venlo, Netherlands. [Vranken, Lisanne; Wyers, Caroline E.; van den Bergh, Joop P. W.] Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Dept Internal Med, Med Ctr MUMC, POB 616, NL-6200 MD Maastricht, Netherlands. [van den Bergh, Joop P. W.; Geusens, Piet P. M. M.] Hasselt Univ, Biomed Res Ctr, Agoralaan, B-3590 Diepenbeek, Belgium. [Geusens, Piet P. M. M.] Maastricht Univ, Dept Internal Med, Subdiv Rheumatol, CAPHRI,Med Ctr MUMC, POB 616, NL-6200 MD Maastricht, Netherlands.
URI: http://hdl.handle.net/1942/24417
DOI: 10.1007/s00223-017-0284-1
ISI #: 000407303100002
ISSN: 0171-967X
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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