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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24398

Title: Population-Wide Impact of Non-Hip Non-Vertebral Fractures on Mortality
Authors: Thach Tran
Bliuc, Dana
van Geel, Tineke
Adachi, Jonathan D.
Berger, Claudie
van den Bergh, Joop P. W.
Eisman, John A.
Geusens, Piet P.M.M.
Goltzman, David
Hanley, David A.
Josse, Robert G.
Kaiser, Stephanie M.
Kovacs, Christopher S.
Langsetmo, Lisa
Prior, Jerilynn C.
Nguyen, Tuan V.
Center, Jacqueline R.
Issue Date: 2017
Publisher: WILEY
Citation: JOURNAL OF BONE AND MINERAL RESEARCH, 32(9), p. 1802-1810
Abstract: Data on long-term consequences of non-hip non-vertebral (NHNV) fractures, accounting for approximately two-thirds of all fragility fractures, are scanty. Our study aimed to quantify the population-wide impact of NHNV fractures on mortality. The national population based prospective cohort study (Canadian Multicentre Osteoporosis Study) included 5526 community dwelling women and 2163 men aged 50 years or older followed from July 1995 to September 2013. Population impact number was used to quantify the average number of people for whom one death would be attributable to fracture and case impact number to quantify the number of deaths out of which one would be attributable to a fracture. There were 1370 fragility fractures followed by 296 deaths in women (mortality rate: 3.49; 95% CI, 3.11 to 3.91), and 302 fractures with 92 deaths in men (5.05; 95% CI, 4.12 to 6.20). NHNV fractures accounted for three-quarters of fractures. In women, the population-wide impact of NHNV fractures on mortality was greater than that of hip and vertebral fractures because of the greater number of NHNV fractures. Out of 800 women, one death was estimated to be attributable to a NHNV fracture, compared with one death in 2000 women attributable to hip or vertebral fracture. Similarly, out of 15 deaths in women, one was estimated to be attributable to a NHNV fracture, compared with one in over 40 deaths for hip or vertebral fracture. The impact of forearm fractures (ie, one death in 2400 women and one out of 42 deaths in women attributable to forearm fracture) was similar to that of hip, vertebral, or rib fractures. Similar, albeit not significant, results were noted for men. The study highlights the important contribution of NHNV fractures on mortality because many NHNV fracture types, except for the most distal fractures, have serious adverse consequences that affect a significant proportion of the population. (C) 2017 American Society for Bone and Mineral Research.
Notes: [Thach Tran; Bliuc, Dana; Adachi, Jonathan D.; Nguyen, Tuan V.; Center, Jacqueline R.] Garvan Inst Med Res, Osteoporosis & Bone Biol, Sydney, NSW, Australia. [van Geel, Tineke] Maastricht Univ, Res Sch Care & Publ Hlth Res Inst CAPHRI, Dept Family Med, Maastricht, Netherlands. [Adachi, Jonathan D.] McMaster Univ, Dept Med, Hamilton, ON, Canada. [Berger, Claudie] McGill Univ, Natl Coordinating Ctr, Canadian Multictr Osteoporosis Study CaMos, Montreal, PQ, Canada. [van den Bergh, Joop] Maastricht Univ, Med Ctr, Res Sch Nutrim, Dept Internal Med,Subdiv Rheumatol, Maastricht, Netherlands. [van den Bergh, Joop] VieCuri Med Ctr Noord Limburg, Dept Internal Med, Venlo, Netherlands. [Eisman, John A.; Center, Jacqueline R.] St Vincents Hosp, Clin Sch, Sydney, NSW, Australia. [Eisman, John A.; Nguyen, Tuan V.; Center, Jacqueline R.] Univ New South Wales, Fac Med, Sydney, NSW, Australia. [Eisman, John A.] Garvan Inst Med Res, Clin Translat & Adv Educ, Sydney, NSW, Australia. [Eisman, John A.] Univ Notre Dame Australia, Sch Med Sydney, Sydney, NSW, Australia. [Geusens, Piet] Maastricht Univ, Med Ctr, Res Sch Care & Publ Hlth Res Inst CAPHRI, Dept Internal Med,Subdiv Rheumatol, Maastricht, Netherlands. [Geusens, Piet] Univ Hasselt, Biomed Res Inst, Hasselt, Belgium. [Goltzman, David] McGill Univ, Dept Med, Montreal, PQ, Canada. [Hanley, David A.] Univ Calgary, Dept Med, Calgary, AB, Canada. [Josse, Robert G.] Univ Toronto, Dept Med, Toronto, ON, Canada. [Kaiser, Stephanie M.] Dalhousie Univ, Dept Med, Halifax, NS, Canada. [Kovacs, Christopher S.] Mem Univ, Fac Med, St John, NF, Canada. [Langsetmo, Lisa] Univ Minnesota, Sch Publ Hlth, Minneapolis, MN USA. [Prior, Jerilynn C.] Univ British Columbia, Dept Med & Endocrinol, Vancouver, BC, Canada.
URI: http://hdl.handle.net/1942/24398
DOI: 10.1002/jbmr.3118
ISI #: 000407675900004
ISSN: 0884-0431
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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