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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24393

Title: Efficacy of a hydroactive colloid gel versus historical controls for the prevention of radiotherapy-induced moist desquamation in breast cancer patients
Authors: Censabella, Sandrine
Claes, Stefan
Orlandini, Marc
Braekers, Roel
Bulens, Paul
Issue Date: 2017
Abstract: Purpose: Radiotherapy-induced moist desquamation (RIMD) is a complication that can affect patients' quality of life and jeopardize radiotherapy outcomes. The curative use of a hydroactive colloid gel has previously been shown effective in the management of RIMD in breast cancer patients. This study aimed at investigating the efficacy of this same gel but in the prevention of RIMD. Methods: A group of breast cancer patients who applied the hydroactive gel from start to end of post lumpectomy radiotherapy (Preventive Hydrogel group) were compared with two groups of matched historical controls: a group applying a dexpanthenol cream throughout their therapy and a group applying first the dexpanthenol cream then, after 11-14 fractions of radiotherapy, the hydroactive gel (Curative Hydrogel group). All patients received identical fractionation regimen. The clinical outcomes were the incidence and time to onset of RIMD. Key results: After 25 fractions of radiotherapy (50 Gy), patients in the Preventive Hydrogel group (N = 202) developed RIMD significantly less frequently and later than patients in the Dexpanthenol group (N = 131; incidence = 7% vs 35% respectively, odds ratios = 7.27; probability of RIMD-free survival after 50 Gy = 0.88 vs 0.62). There were no significant differences between the Preventive and the Curative Hydrogel group (N = 87). Conclusions: These findings confirm our previous results: applying the hydroactive colloid gel, rather than dexpanthenol, delayed the onset and reduced the incidence of RIMD in breast cancer patients. However, applying the hydrogel preventively offered no statistically significant advantages over applying it curatively. (C) 2017 Elsevier Ltd. All rights reserved.
Notes: [Censabella, Sandrine] Tessa Hosp, Div Med Oncol, Stadsomvaart 11, B-3500 Hasselt, Belgium. [Claes, Stefan; Orlandini, Marc; Bulens, Paul] Limburg Oncol Ctr, Stadsomvaart 11, B-3500 Hasselt, Belgium. [Braekers, Roel] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Agoralaan 1, B-3590 Diepenbeek, Belgium. [Braekers, Roel] Katholieke Univ Leuven, Kapucijnenvoer 35,Blok D,Bus 7001, B-3000 Leuven, Belgium.
URI: http://hdl.handle.net/1942/24393
DOI: 10.1016/j.ejon.2017.04.003
ISI #: 000407405700002
ISSN: 1462-3889
Category: A1
Type: Journal Contribution
Validation: ecoom, 2018
Appears in Collections: Research publications

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