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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24387

Title: Predictive factors influencing pregnancy rates after intrauterine insemination with frozen donor semen: a prospective cohort study
Authors: Thijssen, Annelies
Creemers, An
Van der Elst, Wim
Creemers, Eva
Vandormael, Eva
Dhont, Nathalie
Ombelet, Willem
Issue Date: 2017
Citation: REPRODUCTIVE BIOMEDICINE ONLINE, 34(6), p. 590-597
Abstract: The extent to which certain parameters can influence pregnancy rates after intrauterine insemination with frozen donor semen was examined prospectively. Between July 2011 and September 2015, 402 women received 126410 cycles with frozen donor semen in a tertiary referral infertility centre. A case report form was used to collect data prospectively. The primary outcome measure was clinical pregnancy rate (CPR), confirmed by detection of a gestational sac and fetal heartbeat using ultrasonography at 7-8 weeks of gestation. Statistical analysis was carried out using generalized estimating equations (GEE) to account for the correlation between observations from the same patient. Overall, CPR per cycle was 17.2%. Multivariate GEE analysis revealed the following parameters as predictive for a successful pregnancy outcome: female age (P = 0.0003), non-smoking or smoking fewer than 15 cigarettes a day (P = 0.0470 and P = 0.0235, respectively), secondary infertility (P = 0.0062), low progesterone levels at day zero of the cycle (P = 0.0164) and use of ovarian stimulation with HMG and recombinant FSH compared with clomiphene citrate and natural cycle (P = 0.0006 and P = 0.0004, respectively). These parameters were the most important factors influencing the success rate in a sperm donation programme.
Notes: [Thijssen, Annelies; Creemers, Eva; Vandormael, Eva; Dhont, Nathalie; Ombelet, Willem] Genk Inst Fertil Technol, Dept Obstet & Gynecol, Schiepse Bos 6, B-3600 Genk, Belgium. [Thijssen, Annelies; Ombelet, Willem] Hasselt Univ, Dept Physiol, Martelarenlaan 42, B-3500 Hasselt, Belgium. [Creemers, An; Van der Elst, Wim] Hasselt Univ, Ctr Stat CENSTAT, Agoralaan Bldg, B-3590 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/24387
DOI: 10.1016/j.rbmo.2017.03.012
ISI #: 000407004600007
ISSN: 1472-6483
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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