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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24377

Title: Public Health Impact of Congenital Toxoplasmosis and Cytomegalovirus Infection in Belgium, 2013: A Systematic Review and Data Synthesis
Authors: Smit, G. Suzanne A.
Padalko, Elizaveta
Van Acker, Jos
Hens, Niel
Dorny, Pierre
Speybroeck, Niko
Devleesschauwer, Brecht
Issue Date: 2017
Citation: CLINICAL INFECTIOUS DISEASES, 65(4), p. 661-668
Abstract: Congenital toxoplasmosis (CT) and cytomegalovirus infection (cCMV) may cause significant morbidity and even fetal or neonatal mortality. We aimed to quantify the disease burden of CT and cCMV in Belgium in terms of disability-adjusted life years (DALYs) and identify data gaps. The public health impact of CT and cCMV in Belgium in 2013 was 188 (95% uncertainty interval [UI], 43-419) and 1976 (95% UI, 757-4067) DALYs, respectively. The major data gaps identified were representative Belgian studies; information on important sequelae, intrauterine mortality, and termination of pregnancy; and late onset sequelae. A scenario analysis showed important increases in years of life lost when the burden due to fetal losses was included and decreases in DALYs when comprehensive CT prevention measures were conducted. Addressing the key data gaps identified may allow generation of the data needed to break the vicious circle of underrecognition.
Notes: [Smit, G. Suzanne A.; Dorny, Pierre] Univ Ghent, Fac Vet Med, Dept Virol Parasitol & Immunol, Salisburylaan 133, B-9820 Merelbeke, Belgium. [Smit, G. Suzanne A.; Dorny, Pierre] Inst Trop Med, Dept Biomed Sci, Antwerp, Belgium. [Smit, G. Suzanne A.; Speybroeck, Niko] Catholic Univ Louvain, Inst Hlth & Soc, Brussels, Belgium. [Padalko, Elizaveta] Ghent Univ Hosp, Dept Clin Biol Microbiol & Immunol, Diepenbeek, Belgium. [Padalko, Elizaveta] Hasselt Univ, Sch Life Sci, Diepenbeek, Belgium. [Van Acker, Jos] AZ Sint Lucas, Lab Clin Microbiol, Ghent, Belgium. [Hens, Niel] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Diepenbeek, Belgium. [Hens, Niel] Vaccine & Infect Dis Inst, Ctr Hlth Econ Res & Modelling Infect Dis, Antwerp, Belgium. [Hens, Niel] Univ Antwerp, Epidemiol & Social Med, Antwerp, Belgium. [Devleesschauwer, Brecht] Sci Inst Publ Hlth, Dept Publ Hlth & Surveillance, Brussels, Belgium.
URI: http://hdl.handle.net/1942/24377
DOI: 10.1093/cid/cix344
ISI #: 000406670800019
ISSN: 1058-4838
Category: A1
Type: Journal Contribution
Validation: ecoom, 2018
Appears in Collections: Research publications

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