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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24346

Title: Possible Pathogenetic Mechanisms and New Therapeutic Approaches of Pes Equinovarus
Authors: Ostadal, M.
Liskova, J.
Hadraba, Daniel
Eckhardt, A.
Issue Date: 2017
Citation: PHYSIOLOGICAL RESEARCH, 66(3), p. 403-410
Abstract: Idiopathic pes equinovarus (clubfoot) is a congenital deformity of the foot and lower leg defined as a fixation of the foot in plantar flexion, adduction, supination and varus. The deformity does not affect only the foot position, which is usually investigated by radiography, CT, micro-CT, MRI or ultrasound but logically influence the whole gait biomechanics. It is supposed, that clubfoot belongs to a group of fibroproliferative disorders whose origin and multi-hierarchical effect remain unknown. It has been suggested that fibroblasts and growth factors may be involved. To gain a more global view, direct analysis of the protein composition of extracellular matrix, a proteomic approach was used. At present two principle methods are mostly used for the treatment of clubfoot: physiotherapy and the Ponseti method. The determination of the general biological and biomechanical parameters for various regions of the clubfoot can potentially help in the understanding of the mechanisms participating on this serious anomaly and thus contribute to the development of the more efficient therapeutic approach. This review summarizes the present knowledge on the possible pathogenetic mechanisms participating in the development of the clubfoot and their possible relation to the new therapeutic approaches.
Notes: [Ostadal, M.] Univ Hosp Bulovka, Fac Med 1, Dept Orthopaed, Prague, Czech Republic. [Liskova, J.; Hadraba, D.; Eckhardt, A.] Acad Sci Czech Republic, Inst Physiol, Prague, Czech Republic. [Hadraba, D.] Hasselt Univ, Biomed Res Inst, Hasselt, Belgium.
URI: http://hdl.handle.net/1942/24346
Link to publication: www.biomed.cas.cz/physiolres/pdf/66/66_403.pdf
ISI #: 000405692500004
ISSN: 0862-8408
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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