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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24324

Title: Effect of Prepregnancy Pertussis Vaccination in Young Infants
Authors: Maertens, Kirsten
Tran, Mai Phuong Thao
Hens, Niel
Van Damme, Pierre
Leuridan, Elke
Issue Date: 2017
Publisher: OXFORD UNIV PRESS INC
Citation: JOURNAL OF INFECTIOUS DISEASES, 215(12), p. 1855-1861
Abstract: Background. Maternal antibodies to pertussis can hamper infant immune responses to pertussis vaccines. The effect a maternal tetanus, diphtheria, acellular pertussis (Tdap) vaccine booster between 2 consecutive pregnancies is investigated. Methods. A prospective study was conducted in Belgium during 2008-2014 on the kinetics of maternal pertussis antibodies in unvaccinated women and their infants (group A; 86 mother-infant pairs) and in siblings born after the women received Tdap vaccine (group B; 58 mother-infant pairs). Levels of antibody to pertussis toxin, antibody to filamentous hemagglutinin, and antibody to pertactin were measured in maternal blood before and after vaccination and at both deliveries, in cord blood from both siblings, and in infants before and after they received a priming series of acellular pertussis containing vaccines. Results. Levels of pertussis antibodies in all group B siblings at birth were significantly higher than those in their siblings at birth, even as the interval since maternal vaccination increased. Blunting of the infant pertussis vaccine response was detected in group B siblings. We estimated the maximum interval between repeat Tdap vaccine doses in adult women that would yield a beneficial effect for the consecutive infant. Conclusions. Prepregnancy Tdap vaccination significantly increases maternal antibody concentrations in consecutive infants. However, similar to the effect of Tdap vaccination during pregnancy, immune responses of later-born infants born to mothers who received a prepregnancy immunization, are blunted.
Notes: [Maertens, Kirsten; Van Damme, Pierre; Leuridan, Elke] Univ Antwerp, Vaccine & Infect Dis Inst, Ctr Evaluat Vaccinat, Univ Pl 1, B-2610 Antwerp, Belgium. [Hens, Niel] Univ Antwerp, Vaccine & Infect Dis Inst, Ctr Hlth Econ Res & Modeling Infect Dis, Antwerp, Belgium. [Thao Mai Phuong Tran; Hens, Niel] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Hasselt, Belgium.
URI: http://hdl.handle.net/1942/24324
DOI: 10.1093/infdis/jix176
ISI #: 000404380700013
ISSN: 0022-1899
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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