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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24321

Title: The Reliability of a Semi-automated Algorithm for Detection of Cortical Interruptions in Finger Joints on High Resolution CT Compared to MicroCT
Authors: Peters, Martijn
Scharmga, A.
van Tubergen, A.
Arts, J.
Loeffen, D.
Weijers, R.
van Rietbergen, B.
Geusens, Piet
van den Bergh, Joop P. W.
Issue Date: 2017
Publisher: SPRINGER
Citation: CALCIFIED TISSUE INTERNATIONAL, 101(2), p. 132-140
Abstract: We developed a semi-automated algorithm for the detection of cortical interruptions in finger joints using high-resolution peripheral quantitative computed tomography (HR-pQCT). Here, we tested its reliability compared to microCT (A mu CT) as gold standard. Nineteen joints of 10 female anatomic index fingers were imaged by HR-pQCT and A mu CT (82 and 18 A mu m isotropic voxel sizes, respectively). The algorithm was applied for detection of cortical interruptions of different minimum diameters (range > 0.16 to > 0.50 mm). Reliability was tested at the joint level with intra-class correlation coefficient (ICC) for the number of interruptions and interruption surface, and at the level of a single interruption for matching between HR-pQCT and A mu CT with a fixed interruption diameter (> 0.10 mm) on A mu CT. The positive predictive value (PPV0.10mm) and sensitivity(0.10mm) were evaluated. The mean number of interruptions per joint depended on the diameter cut-off and ranged from 3.4 to 53.5 on HR-pQCT and from 1.8 to 45.1 on A mu CT for interruptions > 0.50 to > 0.16 mm, respectively. Reliability at the joint level was almost perfect (ICC >= 0.81) for both the number and surface of interruptions > 0.16 and > 0.33 mm. As expected, the PPV0.10mm increased with increasing interruption diameter from 84.9 to 100%, for interruptions > 0.16 and > 0.50 mm, respectively. However, the sensitivity(0.10mm) decreased with increasing interruption diameter from 62.4 to 4.7%. This semi-automated algorithm for HR-pQCT in finger joints performed best for the detection of cortical interruptions with a minimum diameter of > 0.16 or > 0.33 mm, showing almost perfect reliability at the joint level and interruptions matched with those on A mu CT.
Notes: [Peters, M.; Scharmga, A.; van Tubergen, A.; Geusens, P.; van den Bergh, J. P.] Maastricht Univ, Div Rheumatol, Dept Internal Med, Med Ctr, POB 5800, NL-6202 AZ Maastricht, Netherlands. [Peters, M.; Scharmga, A.; van Tubergen, A.; Geusens, P.] Res Sch CAPHRI, Sch Publ Hlth & Primary Care, Maastricht, Netherlands. [Peters, M.; Scharmga, A.; van den Bergh, J. P.] Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Maastricht, Netherlands. [Arts, J.; van Rietbergen, B.] Maastricht Univ, Dept Orthopaed Surg, Med Ctr, Maastricht, Netherlands. [Arts, J.; van Rietbergen, B.] Eindhoven Univ Technol, Fac Biomed Engn, Eindhoven, Netherlands. [Loeffen, D.; Weijers, R.] Maastricht Univ, Dept Radiol, Med Ctr, Maastricht, Netherlands. [Geusens, P.; van den Bergh, J. P.] Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. [van den Bergh, J. P.] VieCuri Med Ctr, Dept Internal Med, Venlo, Netherlands.
URI: http://hdl.handle.net/1942/24321
DOI: 10.1007/s00223-017-0264-5
ISI #: 000404907500002
ISSN: 0171-967X
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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