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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24309

Title: Incidence and risk factors of fever in a contemporary cohort of HIV-patients with good access to antiretroviral therapy
Authors: De Munter, Paul
Derdelinckx, Inge
Peetermans, Willy E.
Fieuws, Steffen
Vanderschueren, Steven
Van Wijngaerden, Eric
Issue Date: 2017
Publisher: TAYLOR & FRANCIS LTD
Citation: ACTA CLINICA BELGICA, 72(4), p. 226-231
Abstract: Objective: To study incidence and to determine risk factors of fever in a contemporary cohort of HIV-infected patients with access to antiretroviral therapy.Methods: Prospective study in a cohort of HIV-infected patients in Belgium from 2009 to 2013.Results: 759 patients were followed for a total of 2136 patient years. The incidence of fever was low, with an incidence rate of 0.103 (95% CI 0.078; 0.135) febrile episodes per patient per year for temperature 38.3 degrees C or higher measured by a health care provider. Gender, age, ethnicity, and calendar year of measurement were no significant risk factors for fever in univariable analysis, but recent HIV diagnosis, prior AIDS, nadir CD4 cell count, last CD4 cell count, and viral load were, as were use of antiretroviral therapy, recent start of antiretroviral therapy and recent switch of antiretroviral therapy. Recent stop of antiretroviral therapy was no significant risk factor. In multivariable analysis prior AIDS, last CD4 and viral load remained significant risk factors, but use of antiretroviral therapy not.Conclusion: In this contemporary cohort, incidence of fever was low but CD4 cell count less than 200/mm(3) remained associated with the highest incidence of fever.
Notes: [De Munter, Paul; Derdelinckx, Inge; Peetermans, Willy E.; Vanderschueren, Steven; Van Wijngaerden, Eric] Univ Hosp Leuven, Dept Gen Internal Med, Herestr 49, B-3000 Leuven, Belgium. [De Munter, Paul; Derdelinckx, Inge; Peetermans, Willy E.; Vanderschueren, Steven; Van Wijngaerden, Eric] KU Leuven Univ Leuven, Dept Microbiol & Immunol, Leuven, Belgium. [Fieuws, Steffen] Katholieke Univ Leuven, Interuniv Inst Biostat & Stat Bioinformat, Leuven, Belgium. [Fieuws, Steffen] Univ Hasselt, Leuven, Belgium.
URI: http://hdl.handle.net/1942/24309
DOI: 10.1080/17843286.2016.1206240
ISI #: 000403824900002
ISSN: 1784-3286
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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