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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24267

Title: Interleukin-1 Blockade: An Update on Emerging Indications
Authors: Mistry, Anoop
Savic, Sinisa
van der Hilst, Jeroen C.
Issue Date: 2017
Publisher: ADIS INT LTD
Citation: BIODRUGS, 31(3), p. 207-221
Abstract: Interleukin (IL)-1 is a pro-inflammatory cytokine that induces local and systemic inflammation aimed to eliminate microorganisms and tissue damage. However, an increasing number of clinical conditions have been identified in which IL-1 production is considered inappropriate and IL-1 is part of the disease etiology. In autoinflammatory diseases, gout, Schnitzler's syndrome, and adult-onset Still's disease, high levels of inappropriate IL-1 production have been shown to be a key process in the etiology of the disease. In these conditions, blocking IL-1 has proven very effective in clinical studies. In other diseases, IL-1 has shown to be present in disease process but is not the central driving force of inflammation. In these conditions, including type 1 and 2 diabetes mellitus, acute coronary syndrome, amyotrophic lateral sclerosis, and several neoplastic diseases, the benefits of IL-1 blockade are minimal or absent.
Notes: [Mistry, Anoop] St James Univ Hosp, Dept Clin Immunol & Allergy, Wellcome Trust Brenner Bldg,Beckett St, Leeds, W Yorkshire, England. [Savic, Sinisa] St James Univ Hosp, NIH Res Leeds Musculoskeletal Biomed Res Unit NIH, Wellcome Trust Brenner Bldg,Beckett St, Leeds, W Yorkshire, England. [Savic, Sinisa] St James Univ Hosp, Leeds Inst Rheumat & Musculoskeletal Med LIRMM, Wellcome Trust Brenner Bldg,Beckett St, Leeds, W Yorkshire, England. [van der Hilst, Jeroen C. H.] Jessa Hosp, Dept Infect Dis & Immun, Stadsomvaat 11, B-3500 Hasselt, Belgium. [van der Hilst, Jeroen C. H.] Univ Hasselt, Biomed Res Inst, Hasselt, Belgium.
URI: http://hdl.handle.net/1942/24267
DOI: 10.1007/s40259-017-0224-7
ISI #: 000402070900006
ISSN: 1173-8804
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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