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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24230

Title: Plant sterol ester diet supplementation increases serum plant sterols and markers of cholesterol synthesis, but has no effect on total cholesterol levels
Authors: Weingaertner, Oliver
Bogeski, Ivan
Kummerow, Carsten
Schirmer, Stephan H.
Husche, Constanze
Vanmierlo, Tim
Wagenpfeil, Gudrun
Hoth, Markus
Boehm, Michael
Luetjohann, Dieter
Laufs, Ulrich
Issue Date: 2017
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Citation: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 169, p. 219-225
Abstract: This double-blind, randomized, placebo-controlled, cross-over intervention-study was conducted in healthy volunteers to evaluate the effects of plant sterol ester supplemented margarine on cholesterol, non-cholesterol sterols and oxidative stress in serum and monocytes. Sixteen volunteers, average age 34 years, with no or mild hypercholesterolemia were subjected to a 4 week period of daily intake of 3 g plant sterols per day supplied via a supplemented margarine on top of regular eating habits. After a wash-out period of one week, volunteers switched groups. Compared to placebo, a diet supplementation with plant sterols increased serum levels of plant sterols such as campesterol (+0.16 +/- 0.19 mgidL, p = 0.005) and sitosterol (+0.27 +/- 0.18 mg/cIL, p < 0.001) and increased markers of cholesterol synthesis such as desmosterol (+0.05 +/- 0.07 mg/dL, p = 0.006) as well as lathosterol (+0.11 +/- 0.16 mg/dL, p = 0.012). Cholesterol serum levels, however, were not changed significantly (+18.68 +/- 32.6 mg/dL, p = 0.052). These findings could not be verified in isolated circulating monocytes. Moreover, there was no effect on monocyte activation and no differences with regard to redox state after plant sterol supplemented diet. Therefore, in a population of healthy volunteers with no or mild hypercholesterolemia, consumption of plant sterol ester supplemented margarine results in increased concentrations of plant sterols and cholesterol synthesis markers without affecting total cholesterol in the serum, activation of circulating monocytes or redox state.
Notes: [Weingaertner, Oliver; Wagenpfeil, Gudrun] Carl von Ossietzky Univ Oldenburg, European Med Sch Oldenburg Groningen, Abt Kardiol, Klinikum Oldenburg, Oldenburg, Germany. [Schirmer, Stephan H.; Wagenpfeil, Gudrun; Boehm, Michael; Laufs, Ulrich] Klin Innere Med Kardiol Angiol & Internist Intens, Homburg, Germany. [Weingaertner, Oliver; Wagenpfeil, Gudrun] Univ Klinikum Saarlandes, Homburg, Germany. [Weingaertner, Oliver; Wagenpfeil, Gudrun] Univ Klinikum Saarlandes, Inst Med Biometrie Epidemiol & Med Informat, Homburg, Germany. [Bogeski, Ivan; Kummerow, Carsten; Wagenpfeil, Gudrun; Hoth, Markus] Univ Klinikum Saarlandes, Abt Biophys, Homburg, Germany. [Husche, Constanze; Vanmierlo, Tim; Wagenpfeil, Gudrun; Luetjohann, Dieter] Univ Klinikum Bonn, Inst Klin Chem & Klin Pharmakol, Bonn, Germany. [Vanmierlo, Tim] Hasselt Univ, BIOMED, Dept Immunol & Biochem, Hasselt, Belgium. [Hoth, Markus] CIPMM, Fac Med, Dept Biophys, Bldg 48, D-66421 Homburg, Germany.
URI: http://hdl.handle.net/1942/24230
DOI: 10.1016/j.jsbmb.2016.07.016
ISI #: 000401391300025
ISSN: 0960-0760
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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