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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24229

Title: Predictive value of different covariates influencing pregnancy rate following intrauterine insemination with homologous semen: a prospective cohort study
Authors: Thijssen, Annelies
Creemers, An
Van der Elst, Wim
Creemers, Eva
Vandormael, Eva
Dhont, Nathalie
Ombelet, Willem
Issue Date: 2017
Citation: REPRODUCTIVE BIOMEDICINE ONLINE, 34(5), p. 463-472
Abstract: The aim was to examine the value of different covariates in the prediction of intrauterine insemination (IUI) success. Between July 2011 and September 2015, data from 1401 IUI cycles with homologous semen in 556 couples were collected prospectively, by questionnaire, in a tertiary referral infertility centre. Statistical analysis was performed using generalized estimating equations (GEEs). GEEs were used instead of an ordinary logistic regression model to take into account the correlation between observations from the same person. The primary outcome parameter was clinical pregnancy rate (CPR), confirmed with a gestational sac and fetal heartbeat on ultrasonography at 7-8 weeks. An overall CPR of 9.5% per cycle was observed. Uni-variate statistical analysis revealed female and male age, male smoking, female body mass index, ovarian stimulation and inseminating motile count (IMC) as covariates significantly influencing CPR per cycle. Multivariate GEE analysis revealed that the only valuable prognostic covariates included female age, male smoking and infertility status (i.e. primary/secondary infertility). IMC showed a significant curvilinear relationship, with first an increase and then a decrease in pregnancy rate. (C) 2017 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
Notes: [Thijssen, Annelies; Creemers, Eva; Vandormael, Eva; Dhont, Nathalie; Ombelet, Willem] Genk Inst Fertil Technol, Ziekenhuis Oost Limburg, Dept Obstet & Gynecol, Schiepse Bos 6, B-3600 Genk, Belgium. [Thijssen, Annelies; Ombelet, Willem] Hasselt Univ, Dept Physiol, Martelarenlaan 42, B-3500 Hasselt, Belgium. [Creemers, An; Van der Elst, Wim] Hasselt Univ, Ctr Stat CENSTAT, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/24229
DOI: 10.1016/j.rbmo.2017.01.016
ISI #: 000401128200004
ISSN: 1472-6483
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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