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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24207

Title: The effect of paternal methyl-group donor intake on offspring DNA methylation and birth weight
Authors: Pauwels, Sara
Truijen, Ilse
Ghosh, Manosij
Duca, Radu Corneliu
Langie, Sabine A. S.
Bekaert, Bram
Freson, Kathleen
Huybrechts, Inge
Koppen, Gudrun
Devlieger, Roland
Godderis, Lode
Issue Date: 2017
Publisher: CAMBRIDGE UNIV PRESS
Citation: JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, 8(3), p. 311-321
Abstract: Most nutritional studies on the development of children focus on mother-infant interactions. Maternal nutrition is critically involved in the growth and development of the fetus, but what about the father? The aim is to investigate the effects of paternal methyl-group donor intake (methionine, folate, betaine, choline) on paternal and offspring global DNA (hydroxy)methylation, offspring IGF2 DMR DNA methylation, and birth weight. Questionnaires, 7-day estimated dietary records, whole blood samples, and anthropometric measurements from 74 fathers were obtained. A total of 51 cord blood samples were collected and birth weight was obtained. DNA methylation status was measured using liquid chromatography-tandem mass spectrometry (global DNA (hydroxy)methylation) and pyrosequencing (IGF2 DMR methylation). Paternal betaine intake was positively associated with paternal global DNA hydroxymethylation (0.028% per 100 mg betaine increase, 95% CI: 0.003, 0.053, P=0.03) and cord blood global DNA methylation (0.679% per 100 mg betaine increase, 95% CI: 0.057, 1.302, P=0.03). Paternal methionine intake was positively associated with CpG1 (0.336% per 100 mg methionine increase, 95% CI: 0.103, 0.569, P=0.006), and mean CpG (0.201% per 100 mg methionine increase, 95% CI: 0.001, 0.402, P=0.049) methylation of the IGF2 DMR in cord blood. Further, a negative association between birth weight/birth weight-for-gestational age z-score and paternal betaine/methionine intake was found. In addition, a positive association between choline and birth weight/birth weight-for-gestational age z-score was also observed. Our data indicate a potential impact of paternal methyl-group donor intake on paternal global DNA hydroxymethylation, offspring global and IGF2 DMR DNA methylation, and prenatal growth.
Notes: [Pauwels, S.; Truijen, I.; Ghosh, M.; Duca, R. C.; Godderis, L.] Univ Leuven, Dept Publ Hlth & Primary Care, Environm & Hlth, KU Leuven, Kapucijnenvoer 35 Blok Box 7001, B-3000 Leuven, Belgium. [Pauwels, S.; Langie, S. A. S.; Koppen, G.] Flemish Inst Technol Res VITO, Unit Environm Risk & Hlth, Mol, Belgium. [Langie, S. A. S.] Hasselt Univ, Fac Sci, Diepenbeek, Belgium. [Bekaert, B.] Univ Leuven, Dept Imaging & Pathol, KU Leuven, Leuven, Belgium. [Bekaert, B.] Univ Leuven, Univ Hosp Leuven, Dept Forens Med, Lab Forens Genet & Mol Archeol,KU Leuven, Leuven, Belgium. [Freson, K.] Univ Leuven, Ctr Mol & Vasc Biol, KU Leuven, Leuven, Belgium. [Huybrechts, I.] Int Agcy Res Canc, Dietary Exposure Assessment Grp, Lyon, France. [Devlieger, R.] Univ Leuven, Dept Dev & Regenerat, KU Leuven, Leuven, Belgium. [Devlieger, R.] Univ Hosp Leuven, Dept Obstet & Gynecol, Leuven, Belgium. [Godderis, L.] IDEWE, External Serv Prevent & Protect Work, Heverlee, Belgium.
URI: http://hdl.handle.net/1942/24207
DOI: 10.1017/S2040174417000046
ISI #: 000400673600006
ISSN: 2040-1744
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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