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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24199

Title: An automated algorithm for the detection of cortical interruptions on high resolution peripheral quantitative computed tomography images of finger joints
Authors: Peters, Martijn
Scharmga, A.
de Jong, J.
van Tubergen, A.
Geusens, Piet
Arts, J. J.
Loeffen, D.
Weijers, R.
van Rietbergen, B.
van den Bergh, Joop P. W.
Issue Date: 2017
Publisher: PUBLIC LIBRARY SCIENCE
Citation: PLOS ONE, 12(4), p. 1-15 (Art N° e0175829)
Abstract: Objectives To introduce a fully-automated algorithm for the detection of small cortical interruptions (>= 0.246mm in diameter) on high resolution peripheral quantitative computed tomography (HR-pQCT) images, and to investigate the additional value of manual correction of the automatically obtained contours (semi-automated procedure). Methods Ten metacarpophalangeal joints from seven patients with rheumatoid arthritis (RA) and three healthy controls were imaged with HR-pQCT. The images were evaluated by an algorithm according to the fully-and semi-automated procedure for the number and surface of interruptions per joint. Reliability between the fully-and semi-automated procedure and between two independent operators was tested using intra-class correlation coefficient (ICC) and the proportion of matching interruptions. Validity of single interruptions detected was tested by comparing it to visual scoring, as gold standard. The positive predictive value (PPV) and sensitivity were calculated. Results The median number of interruptions per joint was 14 (range 2 to 59) and did not significantly differ between the fully-and semi-automated procedure (p = 0.37). The median interruption surface per joint was significantly higher with the fully-vs. semi-automated procedure (respectively, 8.6mm(2) vs. 5.8mm(2) and 6.1mm(2), p = 0.01). Reliability was almost perfect between the fully-and semi-automated procedure for both the number and surface of interruptions (ICC >= 0.95) and the proportion of matching interruptions was high (>= 76%). Also the inter-operator reliability was almost perfect (ICC >= 0.97, proportion of matching interruptions 92%). The PPV ranged from 27.6% to 29.9%, and sensitivity from 69.7% to 76.3%. Most interruptions detected with the algorithm, did show an interruption on a 2D grayscale image. However, this interruption did not meet the criteria of an interruption with visual scoring. Conclusion The algorithm for HR-pQCT images detects cortical interruptions, and its interruption surface. Reliability and validity was comparable for the fully- and semi-automated procedures. However, we advise the use of the semi-automated procedure to assure quality. The algorithm is a promising tool for a sensitive and objective assessment of cortical interruptions in finger joints assessed by HR-pQCT.
Notes: [Peters, M.; Scharmga, A.; van Tubergen, A.; Geusens, P.; van den Bergh, J.] Maastricht Univ, Med Ctr, Div Rheumatol, Dept Internal Med, Maastricht, Netherlands. [Peters, M.; Scharmga, A.; van Tubergen, A.; Geusens, P.] Maastricht Univ, Sch Publ Hlth & Primary Care, CAPHRI, Maastricht, Netherlands. [Peters, M.; Scharmga, A.; van den Bergh, J.] Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Maastricht, Netherlands. [de Jong, J.; Loeffen, D.; Weijers, R.] Maastricht Univ, Dept Radiol, Med Ctr, Maastricht, Netherlands. [Geusens, P.; van den Bergh, J.] Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. [Arts, J. J.; van Rietbergen, B.] Maastricht Univ, Dept Orthopaed Surg, Med Ctr, Maastricht, Netherlands. [Arts, J. J.; van Rietbergen, B.] Eindhoven Univ Technol, Fac Biomed Engn, Eindhoven, Netherlands. [van den Bergh, J.] VieCuri Med Ctr, Dept Internal Med, Venlo, Netherlands.
URI: http://hdl.handle.net/1942/24199
DOI: 10.1371/journal.pone.0175829
ISI #: 000399875900055
ISSN: 1932-6203
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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