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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24198

Title: Multidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox
Authors: Ogunjimi, Benson
Van den Bergh, Jan
Meysman, P.
Heynderickx, S.
Bergs, K.
Jansen, H.
Leuridan, E.
Vorsters, A.
Goossens, H.
Laukens, K.
Cools, N.
Van Tendeloo, Viggo
Hens, Niel
Van Damme, P.
Smits, Evelien
Beutels, Ph.
Issue Date: 2017
Citation: SCIENTIFIC REPORTS, 7, p. 1-11 (Art N° 1077)
Abstract: Re-exposure to chickenpox may boost varicella-zoster virus (VZV) immunity in the elderly. This secondary immune response is hypothesized to confer protection against herpes zoster. We longitudinally sampled 36 adults over the course of one year after re-exposure to chickenpox. The resulting 183 samples and those of 14 controls were assessed for VZV-specific T-cell immunity and antibody titres. The percentages of VZV-specific CD4+ IL-2-producing T-cells were increased in reexposed grandparents compared to control participants up to 9 months after re-exposure. Using a longitudinal mixture modelling approach, we found that 25% and 17% of re-exposed grandparents showed a boosting of VZV-specific CD4+ IL-2-producing T-cells and VZV-specific antibodies, respectively. The antibody boosting occurred exclusively in cytomegalovirus (CMV) IgG-positive participants. CMV IgG-positive participants also had higher VZV IE62-specific CD4+ IFN-.-producing T-cell percentages and VZV-specific antibody titres. The protective effect of re-exposure to chickenpox is likely limited, as boosting only occurred in 17-25% of the VZV re-exposed grandparents and for less than one year.
Notes: [Ogunjimi, B.; Hens, N.; Beutels, Ph.] Univ Antwerp, Vaccine & Infect Dis Inst VAXINFECTIO, CHERMID, Antwerp, Belgium. [Ogunjimi, B.; Hens, N.] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Hasselt, Belgium. [Ogunjimi, B.] Antwerp Univ Hosp, Dept Pediat, Edegem, Belgium. [Ogunjimi, B.; Van den Bergh, J.; Heynderickx, S.; Cools, N.; Van Tendeloo, Viggo; Smits, Evelien] Univ Antwerp, Vaccine & Infect Dis Inst VAXINFECTIO, LEH, Antwerp, Belgium. [Ogunjimi, B.] Ghent Univ Hosp, Dept Pediat, Ghent, Belgium. [Ogunjimi, B.; Meysman, P.; Laukens, K.; Van Tendeloo, Viggo; Hens, N.; Van Damme, P.; Smits, Evelien; Beutels, Ph.] AUDACIS, Antwerp, Belgium. [Meysman, P.; Laukens, K.] Univ Antwerp, Dept Math & Comp Sci, Adv Database Res & Modelling ADReM, Antwerp, Belgium. [Meysman, P.; Laukens, K.] Univ Antwerp, Antwerp Univ Hosp, Biomed Informat Res Network Antwerp BIOMINA, Edegem, Belgium. [Heynderickx, S.; Van Tendeloo, Viggo; Smits, Evelien] Antwerp Univ Hosp, Ctr Cell Therapy & Regenerat Med, Edegem, Belgium. [Bergs, K.; Jansen, H.; Goossens, H.] Antwerp Univ Hosp, Dept Lab Med, Edegem, Belgium. [Leuridan, E.; Vorsters, A.; Van Damme, P.] Univ Antwerp, Vaccine & Infect Dis Inst VAXINFECTIO, CEV, Antwerp, Belgium. [Goossens, H.] Univ Antwerp, Vaccine & Infect Dis Inst VAXINFECTIO, Lab Med Microbiol, Antwerp, Belgium. [Smits, Evelien] Univ Antwerp, Ctr Oncol Res Antwerp, Antwerp, Belgium. [Beutels, Ph.] Univ New South Wales, Sch Publ Hlth & Community Med, Sydney, NSW, Australia.
URI: http://hdl.handle.net/1942/24198
Link to publication: https://www.researchgate.net/publication/316440735_Multidisciplinary_study_of_the_secondary_immune_response_in_grandparents_re-exposed_to_chickenpox
DOI: 10.1038/s41598-017-0102-8
ISI #: 000400048400001
ISSN: 2045-2322
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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